Evidence map›Paper›PMID 20530020›Full record

ReviewCirculation2010

Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.

Matthias Nahrendorf, Mikael J Pittet, Filip K Swirski

Registry-linked trialAbstract readReview
In one paragraph

Review in Circulation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03829046 (The Effects of Evolocumab on Endothelial and Inflammatory Biocellular Markers in Patients With Diabetes and Atherosclerotic Vascular Disease), which is not on this map. Cited by 446 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
446citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03829046 phase4completedstarted 2019, after this paper: background citation

The Effects of Evolocumab on Endothelial and Inflammatory Biocellular Markers in Patients With Diabetes and Atherosclerotic Vascular Disease (METCHNIKOFF)

Ran2019Enrolled41Registered outcomes11Posted comparisons0ConditionsAtherosclerotic Vascular Disease, Microvascular Dysfunction, Type2 DiabetesArmsEvolocumab, Placebo
Open the trial in the graph
3 · Its place in the literature

Who cites it

446 citing papers in PubMed, 1 synthesis or guideline pooled it.

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386 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, USA. mnahrendorf@mgh.harvard.edu
Mikael J Pittet
Filip K Swirski

Funding

In vivo behavior of monocytes in resting and inflammatory conditionsR01AI084880 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI PITTET, MIKAEL · 2011 to 2020
$4.4M
Monocyte Heterogeneity in Experimental and Human AtherosclerosisR01HL095612 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2009 to 2016
$3.4M
PET/MRI of cardiac repairR01HL096576 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2009 to 2017
$2.8M
Imaging of Cardiac Transplant RejectionR01HL095629 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2009 to 2013
$2.2M
NHLBI NIH HHS R01 HL095612NHLBI NIH HHS R01 HL095629NHLBI NIH HHS R01HL095629NHLBI NIH HHS R01 HL096576NHLBI NIH HHS R01HL096576NIAID NIH HHS R01 AI084880
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsHumansImmunophenotypingInflammationMonocytesMyocardial Infarction

Identifiers

PMID20530020
PMCPMC2892474

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.