ArticleArchives of general psychiatry2010
Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence.
Article in Archives of general psychiatry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02557984 (Dopamine D2/3- and μ-opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity in Healthy Volunteers), which is not on this map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Dopamine D2/3- and μ-opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity in Healthy Volunteers
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 110 citations in OpenAlex.
- Common and separable neural alterations in substance use disorders: A coordinate-based meta-analyses of functional neuroimaging studies in humans.Human brain mapping · 2020Pooled it
- Effects of neuromodulation on cognitive performance in individuals exhibiting addictive behaviors: A systematic review.Drug and alcohol dependence · 2018Pooled it
- Antipsychotic medications for cocaine dependence.The Cochrane database of systematic reviews · 2016Pooled it
- Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.The international journal of neuropsychopharmacology · 2021Trial
- Attention bias modification in drug addiction: Enhancing control of subsequent habits.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial.Drug and alcohol dependence · 2018Trial
- Dopamine, urges to smoke, and the relative salience of drug versus non-drug reward.Social cognitive and affective neuroscience · 2015Trial
- The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues.Addiction (Abingdon, England) · 2014Trial
- Multisite, randomized, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependence.The Journal of clinical psychiatry · 2014Trial
- Individual differences in anterior cingulate activation associated with attentional bias predict cocaine use after treatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Trial
- Brain activation associated with attentional bias in smokers is modulated by a dopamine antagonist.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Evaluation of buspirone for relapse-prevention in adults with cocaine dependence: an efficacy trial conducted in the real world.Contemporary clinical trials · 2012Trial
- Peripheral biomarkers of cognitive response to dopamine receptor agonist treatment.Psychopharmacology · 2011Trial
- Impulsivity is associated with treatment non-completion in cocaine- and methamphetamine-dependent patients but differs in nature as a function of stimulant-dependence diagnosis.Journal of substance abuse treatmentTrial
- Recovery of inhibitory control prefrontal cortex function in inpatients with heroin use disorder: a 15-week longitudinal fMRI study.medRxiv : the preprint server for health sciences · 2023Article
- Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Alcohol- and non-alcohol-related interference: An fMRI study of treatment-seeking adults with alcohol use disorder.Drug and alcohol dependence · 2022Article
- Flexibility of neural circuits regulating mating behaviors in mice and flies.Frontiers in neural circuits · 2022Review
- Impulsivity in cocaine users compared to matched controls: Effects of sex and preferred route of cocaine use.Drug and alcohol dependence · 2021Article
- Orbitofrontal cortex is selectively activated in a primate model of attentional bias to cocaine cues.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
contextThere are no effective pharmacotherapies for stimulant dependence but there are many plausible targets for development of novel therapeutics. We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges.
objectiveTo measure behavioral and brain functional markers of drug-related attentional bias in stimulant-dependent individuals studied repeatedly after short-term dosing with dopamine D(2)/D(3) receptor antagonist and agonist challenges.
designRandomized, double-blind, placebo-controlled, parallel-groups, crossover design using pharmacological functional magnetic resonance imaging.
settingClinical research unit (GlaxoSmithKline) and local community in Cambridge, England.
participantsStimulant-dependent individuals (n = 18) and healthy volunteers (n = 18).
interventionsAmisulpride (400 mg), pramipexole dihydrochloride (0.5 mg), or placebo were administered in counterbalanced order at each of 3 repeated testing sessions.
main outcome measuresAttentional bias for stimulant-related words was measured during functional magnetic resonance imaging by a drug-word Stroop paradigm; trait impulsivity and compulsivity of dependence were assessed at baseline by questionnaire.
resultsDrug users demonstrated significant attentional bias for drug-related words, which was correlated with greater activation of the left prefrontal and right cerebellar cortex. Attentional bias was greater in people with highly compulsive patterns of stimulant abuse; the effects of dopaminergic challenges on attentional interference and related frontocerebellar activation were different between high- and low-compulsivity subgroups.
conclusionsGreater attentional bias for and greater prefrontal activation by stimulant-related words constitute a candidate neurocognitive marker for dependence. Individual differences in compulsivity of stimulant dependence had significant effects on attentional bias, its brain functional representation, and its short-term modulation by dopaminergic challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.