ArticleThe Journal of biological chemistry2010
Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Chondroitin sulfate shapes the unfolded protein response in osteosarcoma to sustain cancer cell survival during ER stress.Cell death & disease · 2026Article
- CD276 immature glycosylation drives colorectal cancer aggressiveness and T cell mediated immune escape.Cell communication and signaling : CCS · 2026Article
- ANGPTL3 regulates the peroxisomal translocation of SmarcAL1 in response to cell growth states.Scientific reports · 2025Article
- Glycosylation Modulation Dictates Trafficking and Interaction of SARS-CoV-2 S1 Subunit and ACE2 in Intestinal Epithelial Caco-2 Cells.Biomolecules · 2024Article
- High-Throughput Mass Spectrometry Analysis ofJournal of proteome research · 2024Article
- Chromatin regulator SMARCAL1 modulates cellular lipid metabolism.Communications biology · 2023Article
- Acetyl-CoA flux from the cytosol to the ER regulates engagement and quality of the secretory pathway.Scientific reports · 2021Article
- Article
- Golgi organization is regulated by proteasomal degradation.Nature communications · 2020Article
- Unlocking Golgi: Why Does Morphology Matter?Biochemistry. Biokhimiia · 2019Review
- Review
- EngineeringRSC advances · 2019Article
- Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.Atherosclerosis · 2018Article
- Bridging the Gap between Glycosylation and Vesicle Traffic.Frontiers in cell and developmental biology · 2016Review
- The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis.Journal of lipid research · 2015Article
- OsCYP21-4, a novel Golgi-resident cyclophilin, increases oxidative stress tolerance in rice.Frontiers in plant science · 2015Article
- Golgi fragmentation induced by heat shock or inhibition of heat shock proteins is mediated by non-muscle myosin IIA via its interaction with glycosyltransferases.Cell stress & chaperones · 2014Article
- Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation.The Journal of biological chemistry · 2013Article
- Mucin-type O-glycosylation during development.The Journal of biological chemistry · 2013Review
- A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites.PLoS pathogens · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nucleotide sugar transporters of the Golgi apparatus play an essential role in the glycosylation of proteins, lipids, and proteoglycans. Down-regulation of expression of the transporters for CMP-sialic acid, GDP-fucose, or both unexpectedly resulted in accumulation of glycoconjugates in the Golgi apparatus rather than in the plasma membrane. Pulse-chase experiments with radiolabeled sugars and amino acids showed decreased synthesis and secretion of both nonglycoproteins and glycoproteins. Further studies revealed that the above silencing induced endoplasmic reticulum stress and inhibited protein translation initiation. Together these results suggest that global inhibition of Golgi apparatus glycosylation may lead to important secondary metabolic changes, unrelated to glycosylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.