ArticleThe Journal of biological chemistry2010
Liganded thyroid hormone receptor-alpha enhances proliferation of pancreatic beta-cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 61 citations in OpenAlex.
- Stromal cells in normal colon and colon cancers: importance of thyroid hormone signaling.Cell death & disease · 2025Review
- Free triiodothyronine and risk of gestational diabetes mellitus: an observational study and Mendelian randomization analysis.Nutrition & metabolism · 2025Article
- Changes in Glucose Intolerance after Treatment with Antithyroid Drugs in Patients with Graves' Disease Using Continuous Glucose Monitoring: A Pilot Study.Internal medicine (Tokyo, Japan) · 2023Article
- Type 1 Diabetes Mellitus and Autoimmune Diseases: A Critical Review of the Association and the Application of Personalized Medicine.Journal of personalized medicine · 2023Review
- Thyroid hormone signaling in the intestinal stem cells and their niche.Cellular and molecular life sciences : CMLS · 2022Review
- p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells.International journal of molecular sciences · 2021Article
- Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study.Frontiers in endocrinology · 2021Article
- Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a "Switch" to the Foetal Gene Programme.Current diabetes reports · 2020Review
- Maternal hypothyroidism in mice influences glucose metabolism in adult offspring.Diabetologia · 2020Article
- Relationship between Free Thyroxine and Islet Beta-cell Function in Euthyroid Subjects.Current medical science · 2020Article
- Thyroid Hormone Changes in Euthyroid Patients with Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets.Frontiers in pharmacology · 2020Review
- Thyroid Hormone Signalling: From the Dawn of Life to the Bedside.Journal of molecular evolution · 2020Review
- Thyroid Dysfunction and Diabetes Mellitus: Two Closely Associated Disorders.Endocrine reviews · 2019Review
- Thyroid hormone receptor α1 as a novel therapeutic target for tissue repair.Annals of translational medicine · 2018Review
- The Roles of Thyroid and Thyroid Hormone in Pancreas: Physiology and Pathology.International journal of endocrinology · 2018Review
- Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts.Frontiers in endocrinology · 2018Review
- Hypothyroidism in utero stimulates pancreatic beta cell proliferation and hyperinsulinaemia in the ovine fetus during late gestation.The Journal of physiology · 2017Article
- The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities.Scientific reports · 2017Article
- Advances in β cell replacement and regeneration strategies for treating diabetes.The Journal of clinical investigation · 2016Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Failure of the functional pancreatic beta-cell mass to expand in response to increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing studies indicate that replication of existing beta-cells is important for beta-cell proliferation in adult animals. In rat pancreatic beta-cell lines (RIN5F), treatment with 100 nM thyroid hormone (triiodothyronine, T(3)) enhances cell proliferation. This result suggests that T(3) is required for beta-cell proliferation or replication. To identify the role of thyroid hormone receptor alpha (TR(alpha)) in the processes of beta-cell growth and cell cycle regulation, we constructed a recombinant adenovirus vector, AdTR(alpha). Infection with AdTR(alpha) to RIN5F cells increased the expression of cyclin D1 mRNA and protein. Overexpression of the cyclin D1 protein in AdTR(alpha)-infected cells led to activation of the cyclin D1/cyclin-dependent kinase/retinoblastoma protein/E2F pathway, along with cell cycle progression and cell proliferation following treatment with 100 nM T(3). Conversely, lowering cellular cyclin D1 by small interfering RNA knockdown in AdTR(alpha)-infected cells led to down-regulation of the cyclin D1/CDK/Rb/E2F pathway and inhibited cell proliferation. Furthermore, in immunodeficient mice with streptozotocin-induced diabetes, intrapancreatic injection of AdTR(alpha) led to the restoration of islet function and to an increase in the beta-cell mass. These results support the hypothesis that liganded TR(alpha) plays a critical role in beta-cell replication and in expansion of the beta-cell mass during postnatal development. Thus, liganded TR(alpha) may be a target for therapeutic strategies that can induce the expansion and regeneration of beta-cells.
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