ArticleEnvironmental health perspectives2010
Particulate air pollution, metabolic syndrome, and heart rate variability: the multi-ethnic study of atherosclerosis (MESA).
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 136 citations in OpenAlex.
- Epidemic Thunderstorm Asthma in China: A Systematic Review of an Artemisia-Associated Phenotype.Clinical reviews in allergy & immunology · 2026Pooled it
- An epidemiological appraisal of the association between heart rate variability and particulate air pollution: a meta-analysis.Heart (British Cardiac Society) · 2012Pooled it
- Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists.Environmental health perspectives · 2011Trial
- CT findings in biomass smoke-associated interstitial lung disease: A retrospective analysis.Journal of clinical imaging science · 2026Article
- Exposure measurement error in air pollution health effect studies: a pooled analysis of personal exposure validation studies in 17 communities across the United States.International journal of environmental health research · 2025Article
- Role of Nighttime Light in the Association Between Air Pollution Exposure and Cardiovascular Disease.Journal of the American Heart Association · 2025Article
- Causal association between PMScientific reports · 2025Article
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Long-Term Exposure to Air Pollution and the Occurrence of Metabolic Syndrome and Its Components in Taiwan.Environmental health perspectives · 2023Article
- Cigarette smoking and PMFrontiers in public health · 2023Article
- Effects of long-term PMEnvironmental health : a global access science source · 2022Article
- Traffic-related air pollution, biomarkers of metabolic dysfunction, oxidative stress, and CC16 in children.Journal of exposure science & environmental epidemiology · 2022Article
- A Co-Twin control study of fine particulate matter and the prevalence of metabolic syndrome risk factors.Environmental research · 2021Article
- Key Characteristics of Cardiovascular Toxicants.Environmental health perspectives · 2021Article
- Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.Environmental research · 2021Article
- Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.Pharmacology & therapeutics · 2021Review
- Particulate matter inhalation and the exacerbation of cardiopulmonary toxicity due to metabolic disease.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- The critical role of endothelial function in fine particulate matter-induced atherosclerosis.Particle and fibre toxicology · 2020Review
- Association of Long-Term Air Pollution with Prevalence and Incidence of Distal Sensorimotor Polyneuropathy: KORA F4/FF4 Study.Environmental health perspectives · 2020Article
- Effect of air pollution on the autonomic modulation of heart rate in overweight adults.Einstein (Sao Paulo, Brazil) · 2020Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCardiac autonomic dysfunction has been suggested as a possible biologic pathway for the association between fine particulate matter ≤ 2.5 µm in diameter (PM2.5) and cardiovascular disease (CVD). We examined the associations of PM2.5 with heart rate variability, a marker of autonomic function, and whether metabolic syndrome (MetS) modified these associations.
methodsWe used data from the Multi-Ethnic Study of Atherosclerosis to measure the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences (rMSSD) of 5,465 participants 45-84 years old who were free of CVD at the baseline examination (2000-2002). Data from the U.S. regulatory monitor network were used to estimate ambient PM2.5 concentrations at the participants' residences. MetS was defined as having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose.
resultsAfter controlling for confounders, we found that an interquartile range (IQR) increase in 2-day average PM2.5 (10.2 µg/m3) was associated with a 2.1% decrease in rMSSD [95% confidence interval (CI), -4.2 to 0.0] and nonsignificantly associated with a 1.8% decrease in SDNN (95% CI, -3.7 to 0.1). Associations were stronger among individuals with MetS than among those without MetS: an IQR elevation in 2-day PM2.5 was associated with a 6.2% decrease in rMSSD (95% CI, -9.4 to -2.9) among participants with MetS, whereas almost no change was found among participants without MetS (p-interaction = 0.005). Similar effect modification was observed in SDNN (p-interaction = 0.011).
conclusionThese findings suggest that autonomic dysfunction may be a mechanism through which PM exposure affects cardiovascular risk, especially among persons with MetS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.