ArticlePsychological medicine2011
Genetic origins of the association between verbal ability and alcohol dependence symptoms in young adulthood.
Article in Psychological medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Association between adolescent alcohol use and cognitive function in young adulthood: A co-twin comparison study.Addiction (Abingdon, England) · 2024Article
- Genetic Profile of Endotoxemia Reveals an Association With Thromboembolism and Stroke.Journal of the American Heart Association · 2021Article
- Predicting Alcohol Dependence Symptoms by Young Adulthood: A Co-Twin Comparisons Study.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2021Article
- Endotoxemia is associated with an adverse metabolic profile.Innate immunity · 2021Article
- Impact of adolescent marijuana use on intelligence: Results from two longitudinal twin studies.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism.PLoS genetics · 2015Article
- Childhood verbal development and drinking behaviors from adolescence to young adulthood: a discordant twin-pair analysis.Alcoholism, clinical and experimental research · 2014Article
- Associations between IQ and alcohol consumption in a population of young males: a large database analysis.Social psychiatry and psychiatric epidemiology · 2013Article
- The association between DRD2/ANKK1 and genetically informed measures of alcohol use and problems.Addiction biology · 2013Article
- The Finnish Twin Cohort Study: an update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Review
- A longitudinal twin study of effects of adolescent alcohol abuse on the neurophysiology of attention and orienting.Alcoholism, clinical and experimental research · 2011Article
- Genetic correlation and gene-environment interaction between alcohol problems and educational level in young adulthood.Journal of studies on alcohol and drugs · 2011Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundCognitive deficits in alcohol dependence (AD) have been observed, poorer verbal ability being among the most consistent findings. Genetic factors influence both cognitive ability and AD, but whether these influences overlap is not known.
methodA subset of 602 monozygotic (MZ) and dizygotic (DZ) twins from FinnTwin16, a population-based study of Finnish twins, was used to study the associations of verbal ability with DSM-III-R diagnosis and symptoms of AD, the maximum number of drinks consumed in a 24-h period, and the Rutgers Alcohol Problem Index (RAPI) scores. These twins, most of them selected for within-pair discordance or concordance for their RAPI scores at age 18.5 years, were studied with neuropsychological tests and interviewed with the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) in young adulthood (mean age 26.2 years, range 23-30 years).
resultsAll alcohol problem measures were associated with lower scores on the Vocabulary subtest of the Wechsler Adult Intelligence Scale - Revised (WAIS-R), a measure of verbal ability. In bivariate genetic models, Vocabulary and the alcohol problem measures had moderate heritabilities (0.54-0.72), and their covariation could be explained by correlated genetic influences (genetic correlations -0.20 to -0.31).
conclusionsPoorer verbal ability and AD have partly overlapping biological etiology. The genetic and environmental influences on the development of cognitive abilities, alcohol problems and risk factors for AD should be studied further with prospective longitudinal designs.
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