ArticleMalaria journal2010
Cerebral malaria: insights from host-parasite protein-protein interactions.
Article in Malaria journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Cerebral malaria in resource-limited African regions: Diagnostic and therapeutic challenges.Infectious medicine · 2026Review
- Is structural hybridization invoking new dimensions for antimalarial drug discovery research?RSC medicinal chemistry · 2023Review
- Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?Frontiers in molecular biosciences · 2022Review
- An Integrative Computational Approach for the Prediction of Human-BioMed research international · 2020Article
- Small Molecule Inhibitors Targeting the Heat Shock Protein System of Human Obligate Protozoan Parasites.International journal of molecular sciences · 2019Review
- Inter-Species/Host-Parasite Protein Interaction Predictions Reviewed.Current bioinformatics · 2018Review
- Metabolic perturbations of kidney and spleen in murine cerebral malaria: (1)H NMR-based metabolomic study.PloS one · 2013Article
- Cytoadherence and severe malaria.The Malaysian journal of medical sciences : MJMS · 2012Article
- Systems biology of fungal infection.Frontiers in microbiology · 2012Article
- Humoral immune responses to Plasmodium falciparum among HIV-1-infected Kenyan adults.Proteomics. Clinical applications · 2011Article
- Atypical manifestations of malaria.Research and reports in tropical medicine · 2011Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral malaria is a form of human malaria wherein Plasmodium falciparum-infected red blood cells adhere to the blood capillaries in the brain, potentially leading to coma and death. Interactions between parasite and host proteins are important in understanding the pathogenesis of this deadly form of malaria. It is, therefore, necessary to study available protein-protein interactions to identify lesser known interactions that could throw light on key events of cerebral malaria.
methodsSequestration, haemostasis dysfunction, systemic inflammation and neuronal damage are key processes of cerebral malaria. Key events were identified from literature as being crucial to these processes. An integrated interactome was created using available experimental and predicted datasets as well as from literature. Interactions from this interactome were filtered based on Gene Ontology and tissue-specific annotations, and further analysed for relevance to the key events.
resultsPfEMP1 presentation, platelet activation and astrocyte dysfunction were identified as the key events influencing the disease. 48896 host-parasite along with other host-parasite, host-host and parasite-parasite protein-protein interactions obtained from a disease-specific corpus were combined to form an integrated interactome. Filtering of the interactome resulted in five host-parasite PPI, six parasite-parasite and two host-host PPI. The analysis of these interactions revealed the potential significance of apolipoproteins and temperature/Hsp expression on efficient PfEMP1 presentation; role of MSP-1 in platelet activation; effect of parasite proteins in TGF-beta regulation and the role of albumin in astrocyte dysfunction.
conclusionsThis work links key host-parasite, parasite-parasite and host-host protein-protein interactions to key processes of cerebral malaria and generates hypotheses for disease pathogenesis based on a filtered interaction dataset. These hypotheses provide novel and significant insights to cerebral malaria.
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