ArticleDiabetology & metabolic syndrome2010
Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions.
Article in Diabetology & metabolic syndrome, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Reversal of diabetic-induced myopathy by swimming exercise in pregnant rats: a translational intervention study.Scientific reports · 2022Article
- Skeletal malformations and growth disturbances in fetuses of mild diabetic ratsBiomedica : revista del Instituto Nacional de Salud · 2021Article
- Article
- Morphological changes in rat rectus abdominis muscle induced by diabetes and pregnancy.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018Article
- Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains.Cardiology research and practice · 2016Article
- Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Extracellular HSP70 levels in diabetic environment in rats.Cell stress & chaperones · 2015Article
- Importance of maternal diabetes on the chronological deregulation of the intrauterine development: an experimental study in rat.Journal of diabetes research · 2015Article
- Impaired peripheral glucose sensing in F1 offspring of diabetic pregnancy.Journal of physiology and biochemistry · 2014Article
- Article
- Neonatally induced mild diabetes: influence on development, behavior and reproductive function of female Wistar rats.Diabetology & metabolic syndrome · 2013Article
- Mild diabetes models and their maternal-fetal repercussions.Journal of diabetes research · 2013Review
- Heat shock protein production and immunity and altered fetal development in diabetic pregnant rats.Cell stress & chaperones · 2013Article
- Modeling chick to assess diabetes pathogenesis and treatment.The review of diabetic studies : RDS · 2011Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many experimental studies have been performed to evaluate mild diabetes effects. However, results are divergent regarding glycemia and insulin measurement, fetal macrossomia, and placental weights. The aim was to investigate repercussions of neonatally-induced mild diabetes on the maternal organism and presence of congenital defects in their offspring in other mild diabetes model. On the day of birth, female offspring were distributed into two groups: Group streptozotocin (STZ): received 100 mg STZ/kg body weight, and Control Group: received vehicle in a similar time period. Maternal weights and glycemias were determined at days 0, 7, 14 and 21 of pregnancy. At day 21 of pregnancy, the rats were anesthetized and a laparotomy was performed to weigh and analyze living fetuses and placentas. The fetuses were classified as small (SPA), appropriate (APA) and large (LPA) for pregnancy age. Fetuses were also analyzed for the presence of external anomalies and processed for skeletal anomaly and ossification sites analysis. Statistical significance was considered as p < 0.05. In STZ group, there was increased glycemia at 0 and 14 days of pregnancy, lower weights throughout pregnancy, higher placental weight and index, an increased proportion of fetuses classified as SPA and LPA, and their fetuses presented with an increased frequency of abnormal sternebra, and absent cervical nuclei, which were not enough to cause the emergence of skeletal anomalies. Thus, this study shows that mild diabetes altered fetal development, characterized by intrauterine growth restriction. Further, the reached glycemia does not lead to any major congenital defects in the fetuses of streptozotocin-induced mild diabetic rats.
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