ArticleGenes, brain, and behavior2010
A genome-wide association study of bipolar disorder and comorbid migraine.
Article in Genes, brain, and behavior, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications.The journal of headache and pain · 2019Pooled it
- Use of next generation sequencing technologies in research and beyond: are participants with mental health disorders fully protected?BMC medical ethics · 2012Pooled it
- Shared genetic risk and causal associations between Post-traumatic stress disorder and migraine with antithrombotic agents and other medications.Neurobiology of stress · 2025Article
- Risk of major mental disorders in the offspring of parents with migraine.Annals of general psychiatry · 2024Article
- A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study.Cephalalgia : an international journal of headache · 2022Article
- Pathophysiological Bases of Comorbidity in Migraine.Frontiers in human neuroscience · 2021Review
- MutatedFrontiers in cell and developmental biology · 2021Article
- A null mutation ofmicroPublication biology · 2020Article
- Von Willebrand factor A domain-containing protein 8 (VWA8) localizes to the matrix side of the inner mitochondrial membrane.Biochemical and biophysical research communications · 2020Article
- Comorbid Bipolar Disorder and Migraine: From Mechanisms to Treatment.Frontiers in psychiatry · 2020Review
- Bipolar disorder and chronic migraine: an open problem.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Subjective cognitive decline in patients with migraine and its relationship with depression, anxiety, and sleep quality.The journal of headache and pain · 2017Article
- Characterization of the novel protein KIAA0564 (Von Willebrand Domain-containing Protein 8).Biochemical and biophysical research communications · 2017Article
- Parental and comorbid migraine in individuals with bipolar disorder: A nationwide register study.Journal of affective disorders · 2016Article
- Rapid cycling as a feature of bipolar disorder and comorbid migraine.Journal of affective disorders · 2015Article
- Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.Journal of affective disorders · 2015Article
- Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB.Journal of affective disorders · 2014Article
- Research resource: identification of novel coregulators specific for thyroid hormone receptor-β2.Molecular endocrinology (Baltimore, Md.) · 2013Article
- A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity.Genetic epidemiology · 2013Article
- Genetic basis of pain variability: recent advances.Journal of medical genetics · 2012Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Both migraine and bipolar affective disorder (BPAD) are complex phenotypes with significant genetic and nongenetic components. Epidemiological and clinical studies have showed a high degree of comorbidity between migraine and BPAD, and overlapping regions of linkage have been shown in numerous genome-wide linkage studies. To identify susceptibility factors for the BPAD/migraine phenotype, we conducted a genome-wide association study (GWAS) in 1001 cases with bipolar disorder collected through the NIMH Genetics Initiative for Bipolar Disorder and genotyped at 1 m single-nucleotide polymorphisms (SNPs) as part of the Genetic Association Information Network (GAIN). We compared BPAD patients without any headache (n = 699) with BPAD patients with doctor diagnosed migraine (n = 56). The strongest evidence for association was found for several SNPs in a 317-kb region encompassing the uncharacterized geneKIAA0564 {e.g. rs9566845 [OR = 4.98 (95% CI: 2.6-9.48), P = 7.7 × 10(-8)] and rs9566867 (P = 8.2 × 10(-8))}. Although the level of significance was significantly reduced when using the Fisher's exact test (as a result of the low count of cases with migraine), rs9566845 P = 1.4 × 10(-5) and rs9566867 P = 1.5 × 10(-5), this region remained the most prominent finding. Furthermore, marker rs9566845 was genotyped and found associated with migraine in an independent Norwegian sample of adult attention deficit hyperactivity disorder (ADHD) patients with and without comorbid migraine (n = 131 and n = 324, respectively), OR = 2.42 (1.18-4.97), P = 0.013. This is the first GWAS examining patients with bipolar disorder and comorbid migraine. These data suggest that genetic variants in the KIAA0564 gene region may predispose to migraine headaches in subgroups of patients with both BPAD and ADHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.