ReviewCritical reviews in biomedical engineering2009
Stem cells for skin tissue engineering and wound healing.
Review in Critical reviews in biomedical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of adult tissue-derived stem cells in chronic leg ulcers: a systematic review focused on tissue regeneration medicine.International wound journal · 2016Pooled it
- Research progress on scar-free healing.Annals of medicine · 2025Review
- The Use of Plant-Derived Extracellular Vesicles in Regenerative Medicine Applied to Cutaneous Wound Healing.Pharmaceutics · 2025Review
- From Bench to Chairside: Collagen Scaffolds in Combination with Mesenchymal Stromal Cells for Gingival Augmentation.Dentistry journal · 2025Article
- Cell migration in diabetic wound healing: Molecular mechanisms and therapeutic strategies (Review).International journal of molecular medicine · 2025Review
- Curcumin-Functionalized Electrospun Nanofibrous Membranes with Antimicrobial Activity for Wound Healing.Nanomaterials (Basel, Switzerland) · 2025Article
- 3D-Bioprinted Skin Tissues for Improving Wound Healing: Current Status and Perspective.Advances in experimental medicine and biology · 2025Review
- Electrospun nanofibrous wound dressings with enhanced efficiency through carbon quantum dots and citrate incorporation.Scientific reports · 2024Article
- Ontogeny of Skin Stem Cells and Molecular Underpinnings.Current issues in molecular biology · 2024Review
- Article
- Autologous Skin Cell Suspension for Full-Thickness Skin Defect Reconstruction: Current Evidence and Health Economic Expectations.Advances in therapy · 2024Article
- Stem Cell-Based Tissue Engineering Approaches for Diabetic Foot Ulcer: a Review from Mechanism to Clinical Trial.Stem cell reviews and reports · 2024Review
- Current Trends on Innovative Technologies in Topical Wound Care for Advanced Healing and Management.Current drug research reviews · 2024Review
- EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs.International journal of molecular sciences · 2023Review
- Skin wound healing as a mirror to cardiac wound healing.Experimental physiology · 2023Review
- Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications.Inflammation and regeneration · 2023Review
- Application of 3D-printed tissue-engineered skin substitute using innovative biomaterial loaded with human adipose-derived stem cells in wound healing.International journal of bioprinting · 2023Article
- Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing.Biomedicines · 2022Review
- Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements.Cells · 2022Review
- A comprehensive review on advancements in tissue engineering and microfluidics toward kidney-on-chip.Biomicrofluidics · 2022Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The tremendous ability of the skin's epidermis to regenerate is due to the presence of epidermal stem cells that continuously produce keratinocytes, which undergo terminal differentiation to a keratinized layer that provides the skin's barrier properties. The ability to control this process in vitro has made it possible to develop various types of tissue-engineered skin grafts, some of which are among the first tissue-engineered products to ever reach the market. In the past 30 years, these products have been applied with some success to the treatment of chronic skin wounds such as diabetic and venous ulcers and deep, acute wounds such as burns. Current technologies remain partially effective in their ability to restore other skin structures, for example, the dermis, which is critical to the overall long-term appearance and function of the skin. As yet, none of these approaches can regenerate skin appendages (e.g. hair follicles and sweat glands). The use of earlier progenitor and stem cells, including embryonic stem cells, is gaining interest in the attempt to overcome such limitations. Furthermore, recent evidence suggests that "adult" stem cells, which are present in the circulation, target areas of injury and likely participate in the wound-healing process. In this paper, we start with an overview of the wound-healing process and current methods used for wound treatment, both conventional and tissue-engineering based. We then review current research on the various types of stem cells used for skin tissue engineering and wound healing, and provide future directions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.