ArticleBiochemistry2010
Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection .
Article in Biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Trends on Potential Boron-containing Drugs by Advancements in Ligand-protein Crystals Complexes.Current medicinal chemistry · 2025Review
- Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis?Current issues in molecular biology · 2023Review
- Towards Arginase Inhibition: Hybrid SAR Protocol for Property Mapping of ChlorinatedInternational journal of molecular sciences · 2023Article
- Nitric oxide in parasitic infections: a friend or foe?Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Review
- Insights into Antimalarial Activity ofMolecules (Basel, Switzerland) · 2022Article
- Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition.The Journal of biological chemistry · 2021Article
- Immunosuppression in Malaria: DoPathogens (Basel, Switzerland) · 2021Review
- Interplay between Plasmodium falciparum haemozoin and L-arginine: implication for nitric oxide production.Malaria journal · 2018Article
- Inverse docking based screening and identification of protein targets for Cassiarin alkaloids againstSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- Uptake and metabolism of arginine impact Plasmodium development in the liver.Scientific reports · 2017Article
- Decreased Rate of Plasma Arginine Appearance in Murine Malaria May Explain Hypoargininemia in Children With Cerebral Malaria.The Journal of infectious diseases · 2016Article
- The Potential of Secondary Metabolites from Plants as Drugs or Leads against Protozoan Neglected Diseases-Part III: In-Silico Molecular Docking Investigations.Molecules (Basel, Switzerland) · 2016Review
- Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.Biochemistry · 2015Article
- Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.Biochemistry · 2014Article
- Reduced erythrocyte deformability associated with hypoargininemia during Plasmodium falciparum malaria.Scientific reports · 2014Article
- Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme.Biochemistry · 2013Article
- Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.Archives of biochemistry and biophysics · 2013Article
- Impact of substrate protonation and tautomerization states on interactions with the active site of arginase I.Journal of chemical information and modeling · 2013Article
- In vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway.BMC microbiology · 2012Article
- Crystal structures of complexes with cobalt-reconstituted human arginase I.Biochemistry · 2011Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The 2.15 A resolution crystal structure of arginase from Plasmodium falciparum, the parasite that causes cerebral malaria, is reported in complex with the boronic acid inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) (K(d) = 11 microM). This is the first crystal structure of a parasitic arginase. Various protein constructs were explored to identify an optimally active enzyme form for inhibition and structural studies and to probe the structure and function of two polypeptide insertions unique to malarial arginase: a 74-residue low-complexity region contained in loop L2 and an 11-residue segment contained in loop L8. Structural studies indicate that the low-complexity region is largely disordered and is oriented away from the trimer interface; its deletion does not significantly compromise enzyme activity. The loop L8 insertion is located at the trimer interface and makes several intra- and intermolecular interactions important for enzyme function. In addition, we also demonstrate that arg- Plasmodium berghei sporozoites show significantly decreased liver infectivity in vivo. Therefore, inhibition of malarial arginase may serve as a possible candidate for antimalarial therapy against liver-stage infection, and ABH may serve as a lead for the development of inhibitors.
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