ArticleJournal of structural and functional genomics2010
To automate or not to automate: this is the question.
Article in Journal of structural and functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Continuous Validation Across Macromolecular Structure Determination Process.Nihon Kessho Gakkai shi · 2023Article
- Optimal structure determination from sub-optimal diffraction data.Protein science : a publication of the Protein Society · 2022Article
- State-of-the-Art Data Management: Improving the Reproducibility, Consistency, and Traceability of Structural Biology and in Vitro Biochemical Experiments.Methods in molecular biology (Clifton, N.J.) · 2021Review
- Advances in methods for atomic resolution macromolecular structure determination.F1000Research · 2020Review
- Molstack-Interactive visualization tool for presentation, interpretation, and validation of macromolecules and electron density maps.Protein science : a publication of the Protein Society · 2018Article
- Refining the macromolecular model - achieving the best agreement with the data from X-ray diffraction experiment.Crystallography reviews · 2018Article
- Fitmunk: improving protein structures by accurate, automatic modeling of side-chain conformations.Acta crystallographica. Section D, Structural biology · 2016Article
- 100 Years later: Celebrating the contributions of x-ray crystallography to allergy and clinical immunology.The Journal of allergy and clinical immunology · 2015Review
- Approaches to automated protein crystal harvesting.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Data management in the modern structural biology and biomedical research environment.Methods in molecular biology (Clifton, N.J.) · 2014Article
- Structural and bioinformatic analysis of the kiwifruit allergen Act d 11, a member of the family of ripening-related proteins.Molecular immunology · 2013Article
- Alternaria alternata allergen Alt a 1: a unique β-barrel protein dimer found exclusively in fungi.The Journal of allergy and clinical immunology · 2012Article
- Graphical tools for macromolecular crystallography in PHENIX.Journal of applied crystallography · 2012Article
- Molecular determinants for antibody binding on group 1 house dust mite allergens.The Journal of biological chemistry · 2012Article
- Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members.The FEBS journal · 2012Article
- Structural and immunologic characterization of Ara h 1, a major peanut allergen.The Journal of biological chemistry · 2011Article
- The Protein Maker: an automated system for high-throughput parallel purification.Acta crystallographica. Section F, Structural biology and crystallization communications · 2011Article
- X-ray crystallography: Assessment and validation of protein-small molecule complexes for drug discovery.Expert opinion on drug discovery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
New protocols and instrumentation significantly boost the outcome of structural biology, which has resulted in significant growth in the number of deposited Protein Data Bank structures. However, even an enormous increase of the productivity of a single step of the structure determination process may not significantly shorten the time between clone and deposition or publication. For example, in a medium size laboratory equipped with the LabDB and HKL-3000 systems, we show that automation of some (and integration of all) steps of the X-ray structure determination pathway is critical for laboratory productivity. Moreover, we show that the lag period after which the impact of a technology change is observed is longer than expected.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.