ArticleBreast cancer research and treatment2011
Aromatase immunoreactivity is increased in mammographically dense regions of the breast.
Article in Breast cancer research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risk factors for breast cancer: an umbrella review of observational cohort studies and causal relationship analysis.Frontiers in oncology · 2025Pooled it
- Effect of preventive hormonal therapy on breast density: a systematic qualitative review.TheScientificWorldJournal · 2014Pooled it
- Trial
- Body mass index-associated gut microbial taxa and functional pathways in women with benign and malignant breast disease.Breast cancer research and treatment · 2026Article
- Metabolic pathways in obesity-related breast cancer.Nature reviews. Endocrinology · 2021Review
- Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer.International journal of molecular sciences · 2021Review
- Pubertal Growth, IGF-1, and Windows of Susceptibility: Puberty and Future Breast Cancer Risk.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2021Article
- Association of Interactions Between Mammographic Density Phenotypes and Established Risk Factors With Breast Cancer Risk, by Tumor Subtype and Menopausal Status.American journal of epidemiology · 2021Article
- Article
- C-C chemokine receptor 5 signaling contributes to cardiac remodeling and dysfunction under pressure overload.Molecular medicine reports · 2021Article
- Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status.Frontiers in oncology · 2021Review
- Adjuvant Therapy and Mammographic Density Changes in Women With Breast Cancer.JNCI cancer spectrum · 2018Article
- In breast cancer subtypes steroid sulfatase (STS) is associated with less aggressive tumour characteristics.British journal of cancer · 2018Article
- The origins of breast cancer associated with mammographic density: a testable biological hypothesis.Breast cancer research : BCR · 2018Article
- Review of quantitative multiscale imaging of breast cancer.Journal of medical imaging (Bellingham, Wash.) · 2018Review
- Adiposity, breast density, and breast cancer risk: epidemiological and biological considerations.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Review
- Tissue-based associations of mammographic breast density with breast stem cell markers.Breast cancer research : BCR · 2017Article
- Aromatase expression in atypical ductal hyperplasia in women.Breast cancer research and treatment · 2017Article
- Stromal characteristics may hold the key to mammographic density: the evidence to date.Oncotarget · 2016Review
- High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium.Breast cancer research : BCR · 2015Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
Mammographic breast density (MBD) is one of the strongest risk factors for breast cancer. Unfortunately, the biologic basis underlying this association is unknown. This study compared aromatase expression or immunoreactivity (IR) in core biopsies from mammographically dense versus non-dense regions of the breast to examine whether estrogen synthesis in the breast is associated with MBD and one possible mechanism through which MBD may influence breast cancer. Eligible participants were 40+ years, had a screening mammogram with visible MBD and no prior cancer or current endocrine therapy. Mammograms were used to identify dense and non-dense regions and ultrasound-guided core biopsies were performed to obtain tissue from these regions. Immunostaining for aromatase employed the streptavidin-biotin amplification method and #677 mouse monoclonal antibody. Aromatase IR was scored in terms of extent and intensity of staining for each cell type (stroma, epithelium, adipocytes) on histologic sections. A modified histological H-score provided quantitation of aromatase IR in each cell type and overall. Repeated measure analyses evaluated average differences (β(H)) in H-score in dense versus non-dense tissue within and across cell types. Forty-nine women with mean age 50 years (range: 40-82), participated. Aromatase IR was increased in dense (vs. non-dense) tissue in both the stroma (β(H) = 0.58) and epithelium (β(H) = 0.12) (P < 0.01). Adipocytes from non-dense tissue, however, had a greater IR compared to those from dense tissue (β(H) = -0.24, P < 0.01). An overall H-score which integrated results from all cell types demonstrated that aromatase IR was twice as great for dense (mean H-score = 0.90, SD = 0.53) versus non-dense (mean H-score = 0.45, SD = 0.39) breast tissue (β(H) = 0.45; P < 0.001). Overall, aromatase IR was greater for mammographically dense versus non-dense tissue and may partly explain how MBD influences breast cancer.
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