ArticleNeurocritical care2010
Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis.
Article in Neurocritical care, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 93 citations in OpenAlex.
- Commentary on "Multiple cortical watershed infarctions following bacterial meningitis".Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- A Case ofInfection and drug resistance · 2026Article
- Cerebral vasculitis secondary to pneumococcal meningitis. Plasmapheresis as adjuvant therapy. Case report.Anaesthesiology intensive therapy · 2025Article
- Cerebrovascular Complications in Bacterial Meningitis.Stroke (Hoboken, N.J.) · 2025Review
- Glucose and Oxygen Levels Modulate the Pore-Forming Effects of Cholesterol-Dependent Cytolysin Pneumolysin fromToxins · 2024Article
- Cerebrovascular complications in patients with community-acquired bacterial meningitis: occurrence and associated factors in the COMBAT multicenter prospective cohort.BMC infectious diseases · 2023Article
- Human Listeriosis.Clinical microbiology reviews · 2023Review
- Article
- Early Intracranial Hemorrhage Predicts Poor Clinical Outcome in Community-Acquired Bacterial Meningitis.Frontiers in neurology · 2022Article
- Measurement of D-dimer in cerebrospinal fluid using a luminescent oxygen channeling immunoassay.Frontiers in neurology · 2022Article
- Atypical Streptococcal Meningitis with Fatal Cerebrovascular Complications: A Case Report.Infectious disease reports · 2020Article
- Infections causing stroke or stroke-like syndromes.Infection · 2020Review
- Adjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.Frontiers in cellular and infection microbiology · 2020Article
- Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia.Journal of neuroinflammation · 2019Article
- [Austrian syndrome: A rare manifestation of invasive pneumococcal disease. A case report and bibliographic review].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019Review
- Expression of cysteinyl leukotriene receptor in brain tissues of rats with Streptococcus pneumoniae meningitis.International journal of clinical and experimental pathology · 2019Article
- Characterization of a Listeria monocytogenes meningitis mouse model.Journal of neuroinflammation · 2018Article
- Late Recovery from SevereCase reports in neurological medicine · 2018Article
- Role of neural barriers in the pathogenesis and outcome ofExperimental and therapeutic medicine · 2017Article
- Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model.Journal of neuroinflammation · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a widely held belief that cerebral infarction after bacterial meningitis is always caused by vasculitis; however, evidence is weak. We hypothesized that diffuse cerebral intravascular coagulation is an additional explanation of cerebral infarction in patients with pneumococcal meningitis.
methodsSixteen brains of adults who died from pneumococcal meningitis were investigated. Clinical data were collected, and brain sections were scored for signs of inflammation and activation of coagulation. Patients with and without cerebral infarction on autopsy were compared.
resultsIn total, 38% of patients had focal neurological deficits. Patients died at a median of 7 days (range, 0-32 days) after admission. On autopsy, the nine patients (56%) with cerebral infarctions more often had arterial thrombosis (p = 0.04) than patients without infarction. Patients with infarction tended to have more inflammatory infiltrations of brain parenchyma, microvascular proliferation, small vessel vasculitis/endarteritis obliterans, blood clotting/vessel clogging, and venous thrombosis. None of the patients had large vessel vasculitis. Five patients had cerebral infarctions without vasculitis or endarteritis obliterans. Although four patients with cerebral infarctions had small vessel vasculitis or endarteritis obliterans, areas of infarction could not be localized to the blood flow distribution of these vessels. Blood clotting/vessel clogging was seen in all four patients with vasculitis or endarteritis obliterans, but this was also observed in 10 patients without vasculitis or endarteritis obliterans. None of the patients developed disseminated intravascular coagulation.
conclusionsOur results suggest that diffuse cerebral intravascular coagulation is an additional explanation of cerebral infarction complicating pneumococcal meningitis.
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