ArticleMolecular genetics and genomics : MGG2010
A copper-transporting ATPase BcCCC2 is necessary for pathogenicity of Botrytis cinerea.
Article in Molecular genetics and genomics : MGG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The multifaceted physiological roles of fungal laccases.Communications biology · 2026Review
- Functional Analysis ofJournal of fungi (Basel, Switzerland) · 2025Article
- A single laccase acts as a key component of environmental sensing in a broad host range fungal pathogen.Communications biology · 2024Article
- The Enigmatic World of Fungal Melanin: A Comprehensive Review.Journal of fungi (Basel, Switzerland) · 2023Review
- Identification and Characterization of the Determinants of Copper Resistance in the Acidophilic FungusApplied and environmental microbiology · 2023Article
- Iron and copper onPeerJ · 2023Article
- Trace copper-mediated asexual developmentFrontiers in microbiology · 2023Article
- Fungal and oomycete pathogens and heavy metals: an inglorious couple in the environment.IMA fungus · 2022Review
- Natural Melanin: Current Trends, and Future Approaches, with Especial Reference to Microbial Source.Polymers · 2022Review
- Quantitative interactions: the disease outcome of Botrytis cinerea across the plant kingdom.G3 (Bethesda, Md.) · 2021Article
- Article
- Trade-Off Relation between Fungicide Sensitivity and Melanin Biosynthesis in Plant Pathogenic Fungi.iScience · 2020Article
- The Destructive Fungal PathogenPathogens (Basel, Switzerland) · 2020Review
- Article
- New insights into copper homeostasis in filamentous fungi.International microbiology : the official journal of the Spanish Society for Microbiology · 2020Review
- Two PFrontiers in microbiology · 2018Article
- Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus.Virulence · 2018Article
- Review
- A Single-Nucleotide Deletion in the Transcription Factor GeneFrontiers in microbiology · 2017Article
- Genome-wide analysis of copper, iron and zinc transporters in the arbuscular mycorrhizal fungus Rhizophagus irregularis.Frontiers in plant science · 2014Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copper is an essential trace element that serves as a cofactor for numerous enzymes. In eukaryotes, copper-transporting ATPases deliver copper to various copper-containing proteins in the trans-golgi network. This study identified a copper-transporting ATPase gene BcCcc2 in a fungus pathogenic to plants, Botrytis cinerea. We investigated the biological roles of BcCCC2 by generating null mutants for BcCcc2. Melanization, conidiation and the formation of sclerotia were severely affected in DeltaBcCcc2 mutants. Moreover, a pathogenicity assay using tomato leaves and carnation petals revealed the mutants to be nonpathogenic. Further analysis indicated that they formed fewer appressoria and infection cushions than the wild-type. These structures were aberrant in morphology and in many cases had a significantly reduced ability to penetrate the plant epidermis. An assay also indicated that DeltaBcCcc2 mutants were defective in infection through wounds. BcCCC2 is necessary not only for penetrating a host but also for fungal growth within plant tissues. Our results also imply that B. cinerea requires copper-containing proteins for infection that are inactive in the absence of the copper-transporting ATPase BcCCC2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.