ArticleNature physics2010
Integrated Elastomeric Components for Autonomous Regulation of Sequential and Oscillatory Flow Switching in Microfluidic Devices.
Article in Nature physics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 272 citations in OpenAlex.
- Microfluidic valves for wearable sweat analysis: a review.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Active Oscillations of Elastic Membranes Arising from the Coupling with a Catalytic Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Living circuit boards built by printing bacterial transistors.Nature chemical biology · 2026Article
- Microfluidic pulse oscillator enabled by a shapeshifting liquid metal capacitor.Nature communications · 2026Article
- Measuring Perfusion Pressure and Flow Resistance in a Microfluidic Device Using an External Optical System.Journal of micro and nano science and engineering · 2026Article
- Physical Intelligence in Small-Scale Robots and Machines.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Measuring Perfusion Pressure and Flow Resistance in a Microfluidic Device Using an External Optical System.bioRxiv : the preprint server for biology · 2025Article
- A Review of the Application of Compliance Phenomenon in Particle Separation Within Microfluidic Systems.Micromachines · 2025Review
- A passive flow microreactor for urine creatinine test.Microsystems & nanoengineering · 2025Article
- Periodic Flows in Microfluidics.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- High-speed fluidic processing circuits for dynamic control of haptic and robotic systems.Science advances · 2024Article
- Article
- Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review.Sensors (Basel, Switzerland) · 2023Review
- Pneumatic computers for embedded control of microfluidics.Science advances · 2023Article
- Cascaded microfluidic circuits for pulsatile filtration of extracellular vesicles from whole blood for early cancer diagnosis.Science advances · 2023Article
- Origami-based integration of robots that sense, decide, and respond.Nature communications · 2023Article
- Phase-Optimized Peristaltic Pumping by Integrated Microfluidic Logic.Micromachines · 2022Article
- Programmable soft valves for digital and analog control.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integrating functional vasculature into organoid culture: A biomechanical perspective.APL bioengineering · 2022Article
- Machine learning for microfluidic design and control.Lab on a chip · 2022Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
A critical need for enhancing usability and capabilities of microfluidic technologies is the development of standardized, scalable, and versatile control systems1,2. Electronically controlled valves and pumps typically used for dynamic flow regulation, although useful, can limit convenience, scalability, and robustness3-5. This shortcoming has motivated development of device-embedded non-electrical flow-control systems. Existing approaches to regulate operation timing on-chip, however, still require external signals such as timed generation of fluid flow, bubbles, liquid plugs or droplets, or an alteration of chemical compositions or temperature6-16. Here, we describe a strategy to provide device-embedded flow switching and clocking functions. Physical gaps and cavities interconnected by holes are fabricated into a three-layer elastomer structure to form networks of fluidic gates that can spontaneously generate cascading and oscillatory flow output using only a constant flow of Newtonian fluids as the device input. The resulting microfluidic substrate architecture is simple, scalable, and should be applicable to various materials. This flow-powered fluidic gating scheme brings the autonomous signal processing ability of microelectronic circuits to microfluidics where there is the added diversity in current information of having distinct chemical or particulate species and richness in current operation of having chemical reactions and physical interactions.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.