ArticleThe Korean journal of internal medicine2010
Correlation of anti-cyclic citrullinated antibody with hand joint erosion score in rheumatoid arthritis patients.
Article in The Korean journal of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Potential Utility of Combined Salivary Calprotectin and Anti-Cyclic Citrullinated Peptide in Rheumatoid Arthritis Assessment.Diagnostics (Basel, Switzerland) · 2025Article
- Rheumatoid Arthritis Co-relation with Anti-CCP Antibodies with special reference to its Prevalence in Asymptomatic First-Degree Relatives.Mediterranean journal of rheumatology · 2022Article
- Article
- Motion analysis of the wrist joints in Chinese rheumatoid arthritis patients: a cross-sectional study.BMC musculoskeletal disorders · 2018Article
- Factors associated with hand joint destruction in Chinese patients with rheumatoid arthritis.BMC musculoskeletal disorders · 2017Article
- Functional disability associated with disease and quality-of-life parameters in Chinese patients with rheumatoid arthritis.Health and quality of life outcomes · 2017Article
- Sleep quality in Chinese patients with rheumatoid arthritis: contributing factors and effects on health-related quality of life.Health and quality of life outcomes · 2016Article
- The role of citrullinated protein antibodies in predicting erosive disease in rheumatoid arthritis: a systematic literature review and meta-analysis.International journal of rheumatology · 2015Review
- Anti-cyclic citrullinated peptide antibodies and paraoxonase-1 polymorphism in rheumatoid arthritis.BMC musculoskeletal disorders · 2014Article
- Anticyclic citrullinated peptide antibody and rheumatoid factor in south Tunisian patients with rheumatoid arthritis: association with disease activity and severity.Journal of clinical laboratory analysis · 2014Article
- Fatigue and severity of rheumatoid arthritis in Moroccan patients.Rheumatology international · 2012Article
- Rheumatoid factor and antibodies against citrullinated peptides in Moroccan patients with rheumatoid arthritis: association with disease parameters and quality of life.Clinical rheumatology · 2012Article
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Authors and funding
6 authors.
Funding
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Abstract
BACKGROUND/
aimsTo examine the correlation between radiological joint damage and serological parameters in early rheumatoid arthritis (RA).
methodsThis retrospective study reviewed the records of 216 patients diagnosed with RA and classified them according to disease duration: group 1, </= 24 months; group 2, > 24 months; and group 3, all patients combined. The extent of joint damage was assessed from plain radiographs using a modified version of the Larsen method and compared among groups.
resultsThe mean radiographic joint damage score was significantly higher in patients who had established RA (10.1 points) compared with those who had early RA. In group 1, the inflammatory parameters, erythrocyte sedimentation rate, and C-reactive protein were positively correlated with the joint damage score, but rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) antibody were not. A subgroup analysis revealed that the anti-CCP positive patients in groups 1 and 2 had greater joint damage scores than did the anti-CCP negative patients, but no difference in RF was observed between subgroups. Anti-CCP positivity was not significantly correlated with joint damage sores in group 3.
conclusionsAnti-CCP positivity was significantly correlated with more severe joint damage at diagnosis. A correlation was observed between the radiological joint damage score and inflammatory parameters in early and established RA, indicating that anti-CCP can serve as a diagnostic tool and predict structural joint damage. These findings suggest anti-CCP positive patients should receive aggressive therapeutic intervention.
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