ArticleNature chemical biology2010
4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.
Article in Nature chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The trial behind it
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Renal coenzyme A (CoA) production from VB5 fuels stem cell proliferation and tumor growth.Nature communications · 2026Article
- 4-nitrobenzoate inhibits 4-hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy.FEBS letters · 2026Article
- Article
- Coenzyme QFree radical biology & medicine · 2025Article
- Coenzyme Q deficiency may predispose to sudden unexplained death via an increased risk of cardiac arrhythmia.International journal of legal medicine · 2024Article
- Resveratrol is converted to the ring portion of coenzyme Q10 and raises intracellular coenzyme Q10 levels in HepG2 cell.Journal of clinical biochemistry and nutrition · 2024Article
- Article
- Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate.FASEB bioAdvances · 2023Article
- Transferrin, insulin, and progesterone modulate intracellular concentrations of coenzyme Q and cholesterol, products of the mevalonate pathway, in undifferentiated PC12 cells.Journal of clinical biochemistry and nutrition · 2023Article
- Coenzyme Q biochemistry and biosynthesis.Trends in biochemical sciences · 2023Review
- Cellular level of coenzyme Q increases with neuronal differentiation, playing an important role in neural elongations.Journal of clinical biochemistry and nutrition · 2022Article
- Reduced prosaposin levels in HepG2 cells with long-term coenzyme Q10 deficiency.Journal of clinical biochemistry and nutrition · 2022Article
- Exploring Ubiquinone Biosynthesis Inhibition as a Strategy for Improving Atovaquone Efficacy in Malaria.Antimicrobial agents and chemotherapy · 2021Article
- Coenzyme Q Depletion Reshapes MCF-7 Cells Metabolism.International journal of molecular sciences · 2020Article
- Quantitative shotgun proteome analysis by direct infusion.Nature methods · 2020Article
- CoQJournal of clinical medicine · 2020Article
- Article
- Vitamin K2 cannot substitute Coenzyme QScientific reports · 2019Article
- Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.eLife · 2018Article
- Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency.Frontiers in physiology · 2017Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coenzyme Q (Q) is an electron transporter in the respiratory chain and a lipid-soluble antioxidant that decreases in humans with age. Here we show that 4-nitrobenzoate inhibited 4-hydroxybenzoate:polyprenyl transferase (Coq2) in a competitive manner and dose-dependently decreased Q in mammalian cells without accumulation of Q intermediates. As 4-nitrobenzoate neither interfered with mitochondrial respiration nor induced oxidative stress, it should prove a valuable tool for studies on both Q deficiency and Q supplementation.
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