ArticleNature nanotechnology2010
Imaging and quantifying the morphology of an organic-inorganic nanoparticle at the sub-nanometre level.
Article in Nature nanotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Advances in Ultrasmall Inorganic Nanoparticles for Nanomedicine: From Diagnosis to Therapeutics.ACS applied materials & interfaces · 2025Review
- Advanced Detection of Pancreatic Cancer Circulating Tumor Cells Using Biomarkers and Magnetic Particle Spectroscopy.Nanotheranostics · 2025Article
- Biochemical transformations of inorganic nanomedicines in buffers, cell cultures and organisms.Nanoscale · 2023Review
- Surfactant Layers on Gold Nanorods.Accounts of chemical research · 2023Article
- Review
- Therapeutic targeting of trained immunity.Nature reviews. Drug discovery · 2019Review
- Quantitative Measure of the Size Dispersity in Ultrasmall Fluorescent Organic-Inorganic Hybrid Core-Shell Silica Nanoparticles by Small-angle X-ray Scattering.Chemistry of materials : a publication of the American Chemical Society · 2019Article
- Recent review of the effect of nanomaterials on stem cells.RSC advances · 2018Review
- Evolution of tribo-induced interfacial nanostructures governing superlubricity in a-C:H and a-C:H:Si films.Nature communications · 2017Article
- Application of EELS and EFTEM to the life sciences enabled by the contributions of Ondrej Krivanek.Ultramicroscopy · 2017Article
- Nanodisco balls: control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles.ACS nano · 2014Article
- Advanced microscopy of star-shaped gold nanoparticles and their adsorption-uptake by macrophages.Metallomics : integrated biometal science · 2013Article
- Development and application of STEM for the biological sciences.Ultramicroscopy · 2012Review
- Label-free identification of single dielectric nanoparticles and viruses with ultraweak polarization forces.Nature materials · 2012Article
- Composition tunable cobalt-nickel and cobalt-iron alloy nanoparticles below 10 nm synthesized using acetonated cobalt carbonyl.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2012Article
- Development of Electron Energy Loss Spectroscopy in the Biological Sciences.MRS bulletin · 2012Article
- Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The application of exosomes as a nanoscale cancer vaccine.International journal of nanomedicine · 2010Review
- Nanoparticles: Dissected with electrons.Nature nanotechnology · 2010Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of hybrid organic-inorganic nanoparticles is of interest for applications such as drug delivery, DNA and protein recognition, and medical diagnostics. However, the characterization of such nanoparticles remains a significant challenge due to the heterogeneous nature of these particles. Here, we report the direct visualization and quantification of the organic and inorganic components of a lipid-coated silica particle that contains a smaller semiconductor quantum dot. High-angle annular dark-field scanning transmission electron microscopy combined with electron energy loss spectroscopy was used to determine the thickness and chemical signature of molecular coating layers, the element atomic ratios, and the exact positions of different elements in single nanoparticles. Moreover, the lipid ratio and lipid phase segregation were also quantified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.