ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- The importance of mechanical conditions in the testing of excitation abnormalities in a population of electro-mechanical models of human ventricular cardiomyocytes.Frontiers in physiology · 2023Article
- CaMKII inhibition reduces arrhythmogenic Ca2+ events in subendocardial cryoinjured rat living myocardial slices.The Journal of general physiology · 2021Article
- The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models.Frontiers in physiology · 2020Article
- A Mathematical Model of the Human Cardiac NaThe Journal of membrane biology · 2019Article
- Transmural cellular heterogeneity in myocardial electromechanics.The journal of physiological sciences : JPS · 2018Article
- Cardiac action potential repolarization revisited: early repolarization shows all-or-none behaviour.The Journal of physiology · 2017Review
- Calcineurin signaling in the heart: The importance of time and place.Journal of molecular and cellular cardiology · 2017Review
- Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle.Circulation. Arrhythmia and electrophysiology · 2014Article
- A compartmentalized mathematical model of the β1-adrenergic signaling system in mouse ventricular myocytes.PloS one · 2014Article
- Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.Journal of molecular and cellular cardiology · 2013Review
- Integrating multi-scale data to create a virtual physiological mouse heart.Interface focus · 2013Article
- Article
- Computational approaches to understand cardiac electrophysiology and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2012Review
- Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.American journal of physiology. Heart and circulatory physiology · 2012Article
- Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-α.American journal of physiology. Heart and circulatory physiology · 2012Article
- Nonequilibrium arrhythmic states and transitions in a mathematical model for diffuse fibrosis in human cardiac tissue.PloS one · 2012Article
- Models of HERG gating.Biophysical journal · 2011Article
- Defining new insight into atypical arrhythmia: a computational model of ankyrin-B syndrome.American journal of physiology. Heart and circulatory physiology · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mouse hearts have a diversity of action potentials (APs) generated by the cardiac myocytes from different regions. Recent evidence shows that cells from the epicardial and endocardial regions of the mouse ventricle have a diversity in Ca(2+) handling properties as well as K(+) current expression. To examine the mechanisms of AP generation, propagation, and stability in transmurally heterogeneous tissue, we developed a comprehensive model of the mouse cardiac cells from the epicardial and endocardial regions of the heart. Our computer model simulates the following differences between epicardial and endocardial myocytes: 1) AP duration is longer in endocardial and shorter in epicardial myocytes, 2) diastolic and systolic intracellular Ca(2+) concentration and intracellular Ca(2+) concentration transients are higher in paced endocardial and lower in epicardial myocytes, 3) Ca(2+) release rate is about two times larger in endocardial than in epicardial myocytes, and 4) Na(+)/Ca(2+) exchanger rate is greater in epicardial than in endocardial myocytes. Isolated epicardial cells showed a higher threshold for stability of AP generation but more complex patterns of AP duration at fast pacing rates. AP propagation velocities in the model of two-dimensional tissue are close to those measured experimentally. Simulations show that heterogeneity of repolarization and Ca(2+) handling are sustained across the mouse ventricular wall. Stability analysis of AP propagation in the two-dimensional model showed the generation of Ca(2+) alternans and more complex transmurally heterogeneous irregular structures of repolarization and intracellular Ca(2+) transients at fast pacing rates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.