ArticleJournal of bacteriology2010
Polar remodeling and histidine kinase activation, which is essential for Caulobacter cell cycle progression, are dependent on DNA replication initiation.
Article in Journal of bacteriology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- TheJournal of bacteriology · 2024Article
- Computational modeling of unphosphorylated CtrA:iScience · 2021Article
- Activation of a signaling pathway by the physical translocation of a chromosome.Developmental cell · 2021Article
- The interplay of spatial organization and biochemistry in building blocks of cellular signalling pathways.Journal of the Royal Society, Interface · 2020Article
- Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin BmSystems · 2019Article
- Regulated Proteolysis in Bacteria: Caulobacter.Annual review of genetics · 2016Review
- Dynamical Localization of DivL and PleC in the Asymmetric Division Cycle of Caulobacter crescentus: A Theoretical Investigation of Alternative Models.PLoS computational biology · 2015Article
- Topological control of the Caulobacter cell cycle circuitry by a polarized single-domain PAS protein.Nature communications · 2015Article
- Cell fate regulation governed by a repurposed bacterial histidine kinase.PLoS biology · 2014Article
- Cell cycle-dependent adaptor complex for ClpXP-mediated proteolysis directly integrates phosphorylation and second messenger signals.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- How do bacteria localize proteins to the cell pole?Journal of cell science · 2014Review
- Computational and genetic reduction of a cell cycle to its simplest, primordial components.PLoS biology · 2013Article
- Potential role of a bistable histidine kinase switch in the asymmetric division cycle of Caulobacter crescentus.PLoS computational biology · 2013Article
- Polarity and cell fate asymmetry in Caulobacter crescentus.Current opinion in microbiology · 2012Review
- Two systems for conditional gene expression in Myxococcus xanthus inducible by isopropyl-β-D-thiogalactopyranoside or vanillate.Journal of bacteriology · 2012Article
- Modularity of the bacterial cell cycle enables independent spatial and temporal control of DNA replication.Current biology : CB · 2011Article
- Bacterial polarity.Current opinion in cell biology · 2011Article
Corrections and comments
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3 authors.
Funding
Abstract
Caulobacter crescentus initiates a single round of DNA replication during each cell cycle. Following the initiation of DNA replication, the essential CckA histidine kinase is activated by phosphorylation, which (via the ChpT phosphotransferase) enables the phosphorylation and activation of the CtrA global regulator. CtrA approximately P then blocks the reinitiation of replication while regulating the transcription of a large number of cell cycle-controlled genes. It has been shown that DNA replication serves as a checkpoint for flagellar biosynthesis and cell division and that this checkpoint is mediated by the availability of active CtrA. Because CckA approximately P promotes the activation of CtrA, we addressed the question of what controls the temporal activation of CckA. We found that the initiation of DNA replication is a prerequisite for remodeling the new cell pole, which includes the localization of the DivL protein kinase to that pole and, consequently, the localization, autophosphorylation, and activation of CckA at that pole. Thus, CckA activation is dependent on polar remodeling and a DNA replication initiation checkpoint that is tightly integrated with the polar phospho-signaling cascade governing cell cycle progression.
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