ArticleThe European respiratory journal2011
Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD.
Article in The European respiratory journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Peripheral blood mononuclear cell gene expression in chronic obstructive pulmonary disease.American journal of respiratory cell and molecular biology · 2013Trial
- Cytokine TGFβ Gene Polymorphism in Asthma: TGF-Related SNP Analysis Enhances the Prediction of Disease Diagnosis (A Case-Control Study With Multivariable Data-Mining Model Development).Frontiers in immunology · 2022Article
- TGF-β gene polimorphisms as risk factors for asthma control among clinic patients.Journal of inflammation (London, England) · 2021Article
- Characteristics and related factors of bronchiectasis in chronic obstructive pulmonary disease.Medicine · 2019Article
- Very low-dose (0.15 mGy) chest CT protocols using the COPDGene 2 test object and a third-generation dual-source CT scanner with corresponding third-generation iterative reconstruction software.Investigative radiology · 2015Article
- Scatter correction associated with dedicated dual-source CT hardware improves accuracy of lung air measures.Academic radiology · 2013Article
- Association of genes of protease-antiprotease balance pathway to lung function and emphysema subtypes.BMC pulmonary medicine · 2013Article
- Article
- The lung in paracoccidioidomycosis: new insights into old problems.Clinics (Sao Paulo, Brazil) · 2013Article
- Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice.PloS one · 2013Article
- Heterozygosity for E292V in ABCA3, lung function and COPD in 64,000 individuals.Respiratory research · 2012Article
- Systems for lung volume standardization during static and dynamic MDCT-based quantitative assessment of pulmonary structure and function.Academic radiology · 2012Article
- Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort.Chest · 2012Article
- Updates on the COPD gene list.International journal of chronic obstructive pulmonary disease · 2012Review
- SERPINE2 haplotype as a risk factor for panlobular type of emphysema.BMC medical genetics · 2011Article
- Equating quantitative emphysema measurements on different CT image reconstructions.Medical physics · 2011Article
- Article
- Bronchial Variation: Anatomical Abnormality May Predispose Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary diseaseReview
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The principal determining factors influencing the development of the airway disease and emphysema components of chronic obstructive pulmonary disease (COPD) have not been clearly defined. Genetic variability in COPD patients might influence the varying degrees of involvement of airway disease and emphysema. Therefore, we investigated the genetic association of single nucleotide polymorphisms (SNPs) in COPD candidate genes for association with emphysema severity and airway wall thickness phenotypes. Polymorphisms in six candidate genes were analysed in 379 subjects of the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study with quantitative chest computed tomography (CT) data. Genetic association with per cent of lung area below -950 HU (LAA950), airway wall thickness, and derived square root wall area (SRWA) of 10-mm internal perimeter airways were investigated. Three SNPs in EPHX1, five SNPs in SERPINE2 and one SNP in GSTP1 were significantly associated with LAA950. Five SNPs in TGFB1, two SNPs in EPHX1, one SNP in SERPINE2 and two SNPs in ADRB2 were associated with airway wall phenotypes in NETT. In conclusion, several COPD candidate genes showed evidence for association with airway wall thickness and emphysema severity using CT in a severe COPD population. Further investigation will be required to replicate these genetic associations for emphysema and airway wall phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.