ArticleSystematic biology2010
Relaxed molecular clocks, the bias-variance trade-off, and the quality of phylogenetic inference.
Article in Systematic biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Phylogenetic and Environmental Insights Into the Biogeography of the Western Blacknose Dace,Ecology and evolution · 2026Article
- Taxonomy, biogeography and evolution of thirty-four taxa inStudies in mycology · 2026Article
- Practical Guide and Review of Fossil Tip-Dating in Phylogenetics.Systematic biology · 2026Review
- Structural phylogenetics unravels the evolutionary diversification of communication systems in gram-positive bacteria and their viruses.Nature structural & molecular biology · 2025Article
- Expectation-Maximization enables Phylogenetic Dating under a Categorical Rate Model.Systematic biology · 2024Article
- Quintet Rooting: rooting species trees under the multi-species coalescent model.Bioinformatics (Oxford, England) · 2022Article
- Log Transformation Improves Dating of Phylogenies.Molecular biology and evolution · 2021Article
- Phylogeographic analyses point to long-term survival on the spot in micro-endemic Lycian salamanders.PloS one · 2020Article
- Latitudinal Biogeographic Structuring in the Globally Distributed MossFrontiers in plant science · 2020Article
- Expert consensus statement on the science of HIV in the context of criminal law.Journal of the International AIDS Society · 2018Article
- Differences in Performance among Test Statistics for Assessing Phylogenomic Model Adequacy.Genome biology and evolution · 2018Article
- Strategies for Partitioning Clock Models in Phylogenomic Dating: Application to the Angiosperm Evolutionary Timescale.Genome biology and evolution · 2017Article
- Article
- Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species.G3 (Bethesda, Md.) · 2016Article
- Evaluating the Adequacy of Molecular Clock Models Using Posterior Predictive Simulations.Molecular biology and evolution · 2015Article
- A revised time tree of the asterids: establishing a temporal framework for evolutionary studies of the coffee family (rubiaceae).PloS one · 2015Article
- Is agriculture driving the diversification of the Bemisia tabaci species complex (Hemiptera: Sternorrhyncha: Aleyrodidae)?: Dating, diversification and biogeographic evidence revealed.BMC evolutionary biology · 2013Article
- A branch-heterogeneous model of protein evolution for efficient inference of ancestral sequences.Systematic biology · 2013Article
- A total-evidence approach to dating with fossils, applied to the early radiation of the hymenoptera.Systematic biology · 2012Article
- The impact of taxon sampling on phylogenetic inference: a review of two decades of controversy.Briefings in bioinformatics · 2012Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Because a constant rate of DNA sequence evolution cannot be assumed to be ubiquitous, relaxed molecular clock inference models have proven useful when estimating rates and divergence dates. Furthermore, it has been recently suggested that using relaxed molecular clocks may provide superior accuracy and precision in phylogenetic inference compared with traditional time-free methods that do not incorporate a molecular clock. We perform a simulation study to determine if assuming a relaxed molecular clock does indeed improve the quality of phylogenetic inference. We analyze sequence data simulated under various rate distributions using relaxed-clocks, strict-clocks, and time-free Bayesian phylogenetic inference models. Our results indicate that no difference exists in the quality of phylogenetic inference between assuming a relaxed molecular clock and making no assumption about the clock-likeness of sequence evolution. This pattern is likely due to the bias-variance trade-off inherent in this type of phylogenetic inference. We also compared the quality of inference between Bayesian and maximum likelihood time-free inference models and found them to be qualitatively similar.
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