ArticleBMC infectious diseases2010
Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Interleukin-10 promoter gene polymorphisms and susceptibility to tuberculosis: a meta-analysis.PloS one · 2015Pooled it
- Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis.Saudi journal of biological sciences · 2021Article
- Population structure and infectious disease risk in southern Africa.Molecular genetics and genomics : MGG · 2017Review
- No significant impact of IFN-γ pathway gene variants on tuberculosis susceptibility in a West African population.European journal of human genetics : EJHG · 2016Article
- Article
- Association between cytokine gene polymorphisms and tuberculosis in a Chinese population in Shanghai: a case-control study.BMC immunology · 2015Article
- Gene polymorphisms in patients with pulmonary tuberculosis from Mozambique.Molecular biology reports · 2015Article
- IL-18 genetic polymorphisms may contribute to the pathogenesis of tuberculosis among Asians: a meta-analysis of case-control studies.Molecular biology reports · 2014Article
- Host genome polymorphisms and tuberculosis infection: What we have to say?The Egyptian journal of chest diseases and tuberculosis · 2014Article
- A panel of ancestry informative markers for the complex five-way admixed South African coloured population.PloS one · 2013Article
- Footprints of genetic susceptibility to pulmonary tuberculosis: cytokine gene variants in north Indians.The Indian journal of medical research · 2012Article
- Association of IFNGR2 gene polymorphisms with pulmonary tuberculosis among the Vietnamese.Human genetics · 2012Article
- Article
- Differential combination of cytokine and interferon- γ +874 T/A polymorphisms determines disease severity in pulmonary tuberculosis.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundInterferon gamma is a major macrophage-activating cytokine during infection with Mycobacterium tuberculosis, the causative pathogen of tuberculosis, and its role has been well established in animal models and in humans. This cytokine is produced by activated T helper 1 cells, which can best deal with intracellular pathogens such as M. tuberculosis. Based on the hypothesis that genes which regulate interferon gamma may influence tuberculosis susceptibility, we investigated polymorphisms in eight candidate genes.
methodsFifty-four polymorphisms in eight candidate genes were genotyped in over 800 tuberculosis cases and healthy controls in a population-based case-control association study in a South African population. Genotyping methods used included the SNPlex Genotyping System, capillary electrophoresis of fluorescently labelled PCR products, TaqMan SNP genotyping assays or the amplification mutation refraction system. Single polymorphisms as well as haplotypes of the variants were tested for association with TB using statistical analyses.
resultsA haplotype in interleukin 12B was nominally associated with tuberculosis (p = 0.02), but after permutation testing, done to assess the significance for the entire analysis, this was not globally significant. In addition a novel allele was found for the interleukin 12B D5S2941 microsatellite.
conclusionsThis study highlights the importance of using larger sample sizes when attempting validation of previously reported genetic associations. Initial studies may be false positives or may propose a stronger genetic effect than subsequently found to be the case.
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