ArticleJournal of experimental & clinical cancer research : CR2010
RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro.
Article in Journal of experimental & clinical cancer research : CR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer.Frontiers in molecular biosciences · 2024Review
- Article
- Correlation betweenPeerJ · 2019Article
- CD147 (EMMPRIN) controls malignant properties of breast cancer cells by interdependent signaling of Wnt and JAK/STAT pathways.Molecular and cellular biochemistry · 2019Article
- Regulation of drug resistance and metastasis of gastric cancer cells via the microRNA647-ANK2 axis.International journal of molecular medicine · 2018Article
- CD147 expression was positively linked to aggressiveness and worse prognosis of gastric cancer: a meta and bioinformatics analysis.Oncotarget · 2017Article
- Upregulation of CD147 Promotes Metastasis of Cholangiocarcinoma by Modulating the Epithelial-to-Mesenchymal Transitional Process.Oncology research · 2017Article
- Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.Seminars in oncology · 2017Review
- Role of miR-647 in human gastric cancer suppression.Oncology reports · 2017Article
- CD147 promotes the proliferation, invasiveness, migration and angiogenesis of human lung carcinoma cells.Oncology letters · 2017Article
- CD147 regulates extrinsic apoptosis in spermatocytes by modulating NFκB signaling pathways.Oncotarget · 2017Article
- CD147 knockdown improves the antitumor efficacy of trastuzumab in HER2-positive breast cancer cells.Oncotarget · 2016Article
- Combination of VP3 and CD147-knockdown enhance apoptosis and tumor growth delay index in colorectal tumor allograft.BMC cancer · 2016Article
- Downregulation of CD147 by chitooligosaccharide inhibits MMP-2 expression and suppresses the metastatic potential of human gastric cancer.Oncology letters · 2014Article
- Expression of CD147 and Lewis y antigen in ovarian cancer and their relationship to drug resistance.Medical oncology (Northwood, London, England) · 2014Article
- CD147 expression in human gastric cancer is associated with tumor recurrence and prognosis.PloS one · 2014Article
- The role of EMMPRIN expression in ovarian epithelial carcinomas.Cell cycle (Georgetown, Tex.) · 2013Article
- An oncolytic adenovirus regulated by a radiation-inducible promoter selectively mediates hSulf-1 gene expression and mutually reinforces antitumor activity of I131-metuximab in hepatocellular carcinoma.Molecular oncology · 2013Article
- Article
- [Construction of a CD147 lentiviral expression vector and establishment of its stably transfected A549 cell line].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities. Enriched on the surface of many tumor cells, CD147 promotes tumor growth, invasion, metastasis and angiogenesis and confers resistance to some chemotherapeutic drugs. In this study, we investigated the possible role of CD147 in the progression of gastric cancer.
methodsShort hairpin RNA (shRNA) expressing vectors targeting CD147 were constructed and transfected into human gastric cancer cells SGC7901 and CD147 expression was monitored by quantitative realtime RT-PCR and Western blot. Cell proliferation, the activities of MMP-2 and MMP-9, the invasive potential and chemosensitivity to cisplatin of SGC7901 cells were determined by MTT, gelatin zymography, Transwell invasion assay and MTT, respectively.
resultsDown-regulation of CD147 by RNAi approach led to decreased cell proliferation, MMP-2 and MMP-9 activities and invasive potential of SGC7901 cells as well as increased chemosensitivity to cisplatin.
conclusionCD147 involves in proliferation, invasion and chemosensitivity of human gastric cancer cell line SGC7901, indicating that CD147 may be a promising therapeutic target for gastric cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.