ArticleBMC infectious diseases2010
Tobramycin at subinhibitory concentration inhibits the RhlI/R quorum sensing system in a Pseudomonas aeruginosa environmental isolate.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 66 citations in OpenAlex.
- Anti-quorum, anti biofilm activity of FDA approved drugs against P. aeruginosa: in silico and in vitro studies.Biotechnology letters · 2026Article
- Effect of Micro-Patterned Mucin on Quinolone and Rhamnolipid Profiles of MucoidACS infectious diseases · 2023Article
- Repurposing Dimetridazole and Ribavirin to disarmFrontiers in microbiology · 2022Article
- Sub-Inhibitory Antibiotic Exposure and Virulence inAntibiotics (Basel, Switzerland) · 2021Review
- Cephalosporins Interfere With Quorum Sensing and Improve the Ability ofFrontiers in microbiology · 2021Article
- Activity of Cinnamaldehyde on Quorum Sensing and Biofilm Susceptibility to Antibiotics inMicroorganisms · 2020Article
- Effect of Sub-Minimum Inhibitory Concentrations of Tyrosol and EDTA on Quorum Sensing and Virulence ofInfection and drug resistance · 2020Article
- Quorum Quenching: A Potential Target for Antipseudomonal Therapy.Infection and drug resistance · 2020Review
- Universal antibiotic tolerance arising from antibiotic-triggered accumulation of pyocyanin in Pseudomonas aeruginosa.PLoS biology · 2019Article
- Effect of subinhibitory concentrations of imipenem and piperacillin onNew microbes and new infections · 2019Article
- Development, Optimization, and Validation of a High Throughput Screening Assay for Identification of Tat and Type II Secretion Inhibitors ofFrontiers in cellular and infection microbiology · 2019Article
- Alterations of growth rate and gene expression levels of UPEC by antibiotics at sub-MIC.Folia microbiologica · 2018Article
- Tobramycin-Treated Pseudomonas aeruginosa PA14 Enhances Streptococcus constellatus 7155 Biofilm Formation in a Cystic Fibrosis Model System.Journal of bacteriology · 2016Article
- Role of quorum sensing in bacterial infections.World journal of clinical cases · 2015Review
- Thiopeptide antibiotics stimulate biofilm formation in Bacillus subtilis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Studies on synthetic LuxR solo hybrids.Frontiers in cellular and infection microbiology · 2015Article
- Sub-inhibitory concentrations of some antibiotics can drive diversification of Pseudomonas aeruginosa populations in artificial sputum medium.BMC microbiology · 2013Article
- The apparent quorum-sensing inhibitory activity of pyrogallol is a side effect of peroxide production.Antimicrobial agents and chemotherapy · 2013Article
- Doxycycline interferes with quorum sensing-mediated virulence factors and biofilm formation in gram-negative bacteria.World journal of microbiology & biotechnology · 2013Article
- Complex marine natural products as potential epigenetic and production regulators of antibiotics from a marine Pseudomonas aeruginosa.Microbial ecology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotics are not only small molecules with therapeutic activity in killing or inhibiting microbial growth, but can also act as signaling molecules affecting gene expression in bacterial communities. A few studies have demonstrated the effect of tobramycin as a signal molecule on gene expression at the transcriptional level and its effect on bacterial physiology and virulence. These have shown that subinhibitory concentrations (SICs) of tobramycin induce biofilm formation and enhance the capabilities of P. aeruginosa to colonize specific environments.
methodsEnvironmental P. aeruginosa strain PUPa3 was grown in the presence of different concentrations of tobramycin and it was determined at which highest concentration SIC, growth, total protein levels and translation efficiency were not affected. At SIC it was then established if phenotypes related to cell-cell signaling known as quorum sensing were altered.
resultsIn this study it was determined whether tobramycin sensing/response at SICs was affecting the two independent AHL QS systems in an environmental P. aeruginosa strain. It is reasonable to assume that P. aeruginosa encounters tobramycin in nature since it is produced by niche mate Streptomyces tenebrarius. It was established that SICs of tobramycin inhibited the RhlI/R system by reducing levels of C4-HSL production. This effect was not due to a decrease of rhlI transcription and required tobramycin-ribosome interaction.
conclusionsTobramycin signaling in P. aeruginosa occurs and different strains can have a different response. Understanding the tobramycin response by an environmental P. aeruginosa will highlight possible inter-species signalling taking place in nature and can possible also have important implications in the mode of utilization for human use of this very important antibiotic.
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