ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2008
Is obesity associated with an increased risk for airway hyperresponsiveness and development of asthma?
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of obesity on airway remodeling in asthma: pathophysiological insights and clinical implications.Frontiers in allergy · 2024Review
- Meta-omics profiling of the gut-lung axis illuminates metabolic networks and host-microbial interactions associated with elevated lung elastance in a murine model of obese allergic asthma.Frontiers in microbiomes · 2023Article
- The relationship between body mass index and increased airway reactivity based on methacholine challenge test results.Postepy dermatologii i alergologii · 2017Article
- Metabolic origins of childhood asthma.Molecular and cellular pediatrics · 2015Article
- Central obesity and other factors associated with uncontrolled asthma in women.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2015Article
- High-fat diet promotes lung fibrosis and attenuates airway eosinophilia after exposure to cockroach allergen in mice.Experimental lung research · 2013Article
- Obesity can influence children's and adolescents' airway hyperresponsiveness differently.Multidisciplinary respiratory medicine · 2013Article
- Distal airway impairment in obese normoreactive women.BioMed research international · 2013Article
- Obesity and asthma: physiological perspective.Journal of allergy · 2013Article
- The asthma phenotype in the obese: distinct or otherwise?Journal of allergy · 2013Article
- BMI can influence adult males' and females' airway hyperresponsiveness differently.Multidisciplinary respiratory medicine · 2012Article
- Associations of asthma with body mass index and adult weight change among reproductive age women.The Journal of asthma : official journal of the Association for the Care of Asthma · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
: We investigated the association between airway hyperresponsiveness (AHR) and obesity in adults referred for confirmation of asthma diagnosis. Data were analyzed for obesity class I (body mass index [BMI] 30-34.9 kg/m2), class II (BMI >/= 35-39.9 kg/m2), and class III (BMI >/= 40 kg/m2). Of 861 subjects, 401 demonstrated AHR; the mean dose of methacholine was 4.16 +/- 2.55 mg/mL. A significant association between obesity and AHR was evident for all subjects: the odds ratio was 1.37 (95% CI 1.02-1.82; p = .0317). One unit of increased BMI (1 kg/m2) was associated with a 3.1% increase in AHR risk (95% CI 1.01-1.05, p < .005). The odds ratio increased from 1.86 (95% CI 1.27-1.76; p = .0012) for class I to 2.61 (95% CI 1.48-4.60; p = .0006) for class III. Obesity was found to be associated with AHR and appears to be a risk factor for asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.