ArticleTraffic (Copenhagen, Denmark)2010
Cdc42 regulates microtubule-dependent Golgi positioning.
Article in Traffic (Copenhagen, Denmark), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 37 citations in OpenAlex.
- A Wet-and-Dry Research Model: Unveiling Biomechanics in Odontoblast Polarization.International endodontic journal · 2026Article
- Cx43 levels guide apicobasal polarity in regenerating airway epithelial cells.Communications biology · 2026Article
- Multiple roles for actin in secretory and endocytic pathways.Current biology : CB · 2021Review
- Cytokinetic bridge triggers de novo lumen formation in vivo.Nature communications · 2020Article
- Review
- Abnormal Golgi morphology and decreased COPI function in cells with low levels of SMN.Brain research · 2019Article
- A New Look at the Functional Organization of the Golgi Ribbon.Frontiers in cell and developmental biology · 2019Article
- Multifaceted Rho GTPase Signaling at the Endomembranes.Frontiers in cell and developmental biology · 2019Review
- Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.Scientific reports · 2018Article
- A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions.eLife · 2018Article
- Cell Migration in Microfabricated 3D Collagen Microtracks is Mediated through the Prometastatic Protein Girdin.Cellular and molecular bioengineering · 2018Article
- Crosstalk of cell polarity signaling pathways.Protoplasma · 2017Review
- Cdc42 and Cellular Polarity: Emerging Roles at the Golgi.Trends in cell biology · 2016Review
- Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration.Molecular biology of the cell · 2016Article
- Article
- Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Current biology : CB · 2014Review
- Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion.Cell host & microbe · 2014Article
- Rab11 endosomes contribute to mitotic spindle organization and orientation.Developmental cell · 2014Article
- CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.PloS one · 2014Article
- Reelin promotes microtubule dynamics in processes of developing neurons.Histochemistry and cell biology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The molecular mechanisms underlying cytoskeleton-dependent Golgi positioning are poorly understood. In mammalian cells, the Golgi apparatus is localized near the juxtanuclear centrosome via dynein-mediated motility along microtubules. Previous studies implicate Cdc42 in regulating dynein-dependent motility. Here we show that reduced expression of the Cdc42-specific GTPase-activating protein, ARHGAP21, inhibits the ability of dispersed Golgi membranes to reposition at the centrosome following nocodazole treatment and washout. Cdc42 regulation of Golgi positioning appears to involve ARF1 and a binding interaction with the vesicle-coat protein coatomer. We tested whether Cdc42 directly affects motility, as opposed to the formation of a trafficking intermediate, using a Golgi capture and motility assay in permeabilized cells. Disrupting Cdc42 activation or the coatomer/Cdc42 binding interaction stimulated Golgi motility. The coatomer/Cdc42-sensitive motility was blocked by the addition of an inhibitory dynein antibody. Together, our results reveal that dynein and microtubule-dependent Golgi positioning is regulated by ARF1-, coatomer-, and ARHGAP21-dependent Cdc42 signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.