ArticleThe Plant journal : for cell and molecular biology2010
A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis.
Article in The Plant journal : for cell and molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.
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117 citing papers in PubMed, 252 citations in OpenAlex.
- OsMAPK6 Phosphorylates and Degrades OsCATA to Regulate HMolecular plant pathology · 2026Article
- Rice roots recruit Bacillus via the secretion of heptadecanoic acid.Nature plants · 2026Article
- Jacalin-Related LectinPlants (Basel, Switzerland) · 2026Article
- MAPK regulates secondary metabolism and abiotic stress in horticultural and medicinal plants.Horticulture research · 2026Article
- Uncovering the Molecular Response of Oregano (Current issues in molecular biology · 2025Article
- Innovative metabolic reprogramming in rice: unlocking drought resilience through microbial consortia interaction and sustainable agriculture.3 Biotech · 2025Review
- OsCDPK24 and OsCDPK28 phosphorylate heat shock factor OsHSFA4d to orchestrate abiotic and biotic stress responses in rice.Nature communications · 2025Article
- Transcriptional Dynamics of Receptor-Based Genes Reveal Immunity Hubs in Rice Response toInternational journal of molecular sciences · 2025Article
- Article
- Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation inFrontiers in plant science · 2025Article
- Phosphorylation of the transcription factor OsNAC29 by OsMAPK3 activates diterpenoid genes to promote rice immunity.The Plant cell · 2024Article
- Mining of Candidate Genes and Developing Molecular Markers Associated with Pokkah Boeng Resistance in Sugarcane (Plants (Basel, Switzerland) · 2024Article
- The OsMAPK5-OsWRKY72 module negatively regulates grain length and grain weight in rice.Journal of integrative plant biology · 2024Article
- OsWRKY70 Plays Opposite Roles in Blast Resistance and Cold Stress Tolerance in Rice.Rice (New York, N.Y.) · 2024Article
- Post-Translational Modification of WRKY Transcription Factors.Plants (Basel, Switzerland) · 2024Review
- OsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate.Nature communications · 2024Article
- Identification and analysis of MAPK cascade gene families of Camellia oleifera and their roles in response to cold stress.Molecular biology reports · 2024Article
- The Transcription Factors AcuK and AcuM Influence Siderophore Biosynthesis ofJournal of fungi (Basel, Switzerland) · 2024Article
- Multi-omics revealed molecular mechanism of biphenyl phytoalexin formation in response to yeast extract-induced oxidative stress in Sorbus aucuparia suspension cells.Plant cell reports · 2024Article
- Transcriptomics reveals a core transcriptional network of K-type cytoplasmic male sterility microspore abortion in wheat (Triticum aestivum L.).BMC plant biology · 2023Article
57 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plants recognize potential microbial pathogens through microbial-associated molecular patterns (MAMPs) and activate a series of defense responses, including cell death and the production of reactive oxygen species (ROS) and diverse anti-microbial secondary metabolites. Mitogen-activated protein kinase (MAPK) cascades are known to play a pivotal role in mediating MAMP signals; however, the signaling pathway from a MAPK cascade to the activation of defense responses is poorly understood. Here, we found in rice that the chitin elicitor, a fungal MAMP, activates two rice MAPKs (OsMPK3 and OsMPK6) and one MAPK kinase (OsMKK4). OsMPK6 was essential for the chitin elicitor-induced biosynthesis of diterpenoid phytoalexins. Conditional expression of the active form of OsMKK4 (OsMKK4(DD) ) induced extensive alterations in gene expression, which implied dynamic changes of metabolic flow from glycolysis to secondary metabolite biosynthesis while suppressing basic cellular activities such as translation and cell division. OsMKK4(DD) also induced various defense responses, such as cell death, biosynthesis of diterpenoid phytoalexins and lignin but not generation of extracellular ROS. OsMKK4(DD) -induced cell death and expression of diterpenoid phytoalexin pathway genes, but not that of phenylpropanoid pathway genes, were dependent on OsMPK6. Collectively, the OsMKK4-OsMPK6 cascade plays a crucial role in reprogramming plant metabolism during MAMP-triggered defense responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.