ArticleACS chemical biology2010
Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens.
Article in ACS chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- Global transcriptomics and targeted metabolite analysis reveal the involvement of the AcrAB efflux pump in physiological functions by exporting signaling molecules inMicrobiology spectrum · 2025Article
- Prokaryotic Solute/Sodium Symporters: Versatile Functions and Mechanisms of a Transporter Family.International journal of molecular sciences · 2021Review
- Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA.Nature microbiology · 2020Article
- Bacterial Autoimmune Drug Metabolism Transforms an Immunomodulator into Structurally and Functionally Divergent Antibiotics.Angewandte Chemie (International ed. in English) · 2020Article
- Secondary Metabolites Produced byJournal of nematology · 2017Article
- Stilbene epoxidation and detoxification in aThe Journal of biological chemistry · 2017Article
- Article
- LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis inPeerJ · 2017Article
- HexA is a versatile regulator involved in the control of phenotypic heterogeneity of Photorhabdus luminescens.PloS one · 2017Article
- Solid-phase enrichment and analysis of electrophilic natural products.Beilstein journal of organic chemistry · 2017Article
- The Global Regulators Lrp, LeuO, and HexA Control Secondary Metabolism in Entomopathogenic Bacteria.Frontiers in microbiology · 2017Article
- Heterogeneous regulation of bacterial natural product biosynthesis via a novel transcription factor.Heliyon · 2016Article
- The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms.Marine drugs · 2015Review
- Animals in a bacterial world: opportunities for chemical ecology.Natural product reports · 2015Review
- Lumiquinone A, an α-Aminomalonate-Derived Aminobenzoquinone from Photorhabdus luminescens.Journal of natural products · 2015Article
- Merging chemical ecology with bacterial genome mining for secondary metabolite discovery.Journal of industrial microbiology & biotechnology · 2014Review
- The expression of stlA in Photorhabdus luminescens is controlled by nutrient limitation.PloS one · 2013Article
- Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.PloS one · 2012Article
- Statistical optimization of process variables for antibiotic activity of Xenorhabdus bovienii.PloS one · 2012Article
- Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.Chemistry & biology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Bacterially produced small molecules demonstrate a remarkable range of structural and functional diversity and include some of our most useful biological probes and therapeutic agents. Annotations of bacterial genomes reveal a large gap between the number of known small molecules and the number of biosynthetic genes/loci that could produce such small molecules, a gap that most likely originates from tight regulatory control by the producing organism. This study coupled a global transcriptional regulator, HexA, to secondary metabolite production in Photorhabdus luminescens, a member of the Gammaproteobacteria that participates in a complex symbiosis with nematode worms and insect larvae. HexA is a LysR-type transcriptional repressor, and knocking it out to create a P. luminescens DeltahexA mutant led to dramatic upregulation of biosynthesized small molecules. Use of this mutant expanded a family of stilbene-derived small molecules, which were known to play important roles in the symbiosis, from three members to at least nine members.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.