ArticleInternational urology and nephrology2011
Antimicrobial susceptibility of pediatric uropathogens in Thrace, Greece.
Article in International urology and nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Pediatric Urinary Antimicrobial Resistance Patterns in a Tertiary Hospital of Northern Greece: A Retrospective Laboratory-Based Surveillance Study.Antibiotics (Basel, Switzerland) · 2026Article
- In vitro antimicrobial activity and clinical use of trimethoprim-sulfamethoxazole for infections due to KPC-producing Gram-negative pathogens: a review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Review
- A national study of antibiotic use in Greek pediatric hematology oncology and bone marrow transplant units.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2022Article
- Pattern of Antibacterial Resistance in Urinary Tract Infections: A Systematic Review and Meta-analysis.International journal of preventive medicine · 2019Review
- Antibiotic Resistance in Pediatric Urinary Tract Infections.Current infectious disease reports · 2016Review
- Global assessment of antimicrobial susceptibility among Gram-negative organisms collected from pediatric patients between 2004 and 2012: results from the Tigecycline Evaluation and Surveillance Trial.Journal of clinical microbiology · 2015Article
- Long-term resistance trends of uropathogens and association with antimicrobial prophylaxis.Pediatric nephrology (Berlin, Germany) · 2014Article
- Update on recent guidelines for the management of urinary tract infections in children: the shifting paradigm.Current opinion in pediatrics · 2013Review
- Clinical Value of an Ambulatory-Based Antibiogram for Uropathogens in Children.Journal of the Pediatric Infectious Diseases Society · 2012Article
- Antimicrobial resistance of uropathogens in women with acute uncomplicated cystitis from primary care settings.International urology and nephrology · 2011Article
Corrections and comments
- Erratum issuedFalagas, Mathew [corrected to Falagas, Mathew E]
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the bacterial pathogens involved in pediatric urinary tract infections (UTIs) in a tertiary general hospital located in the Thrace province of Northern Greece over a 69-month period (1/2003 to 9/2008), and their antibiotic susceptibility patterns. A total of 622 episodes of UTIs in 508 children were identified. Median age of all children was 16 months (range 1 month to 14 years). Boys were significantly younger than girls (9 months vs. 24 months). Escherichia coli was the most common uropathogen and responsible for 69.1% of UTIs. Approximately half of E. coli isolates were resistant to ampicillin and 20.5% to trimethoprim/sulfamethoxazole (TMP/SMX). E. coli resistance to second-generation and third-generation cephalosporins was <4%, to aminoglycosides <8%, and to nitrofurantoin 4.4%. Pediatric E. coli urine isolates were significantly more resistant to ampicillin and ticarcillin and more sensitive to quinolones compared to adult E. coli uropathogens identified in the same hospital. E. coli resistance to ampicillin and amoxicillin/clavulanic acid was significantly higher in boys 12-23 months-old compared to girls of the same age. In conclusion, nitrofurantoin is a very good choice for chemoprophylaxis. Amoxicillin/clavulanic acid, second-generation cephalosporins, and TMP/SMX are appropriate choices for oral empirical treatment of UTIs. Parenteral aminoglycosides and second and third-generation cephalosporins are excellent treatment choices for inpatient therapy. Finally, sex and age are additional factors that should be taken into account when choosing empirical therapy for children with UTIs.
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