ArticleLung2010
Association of IL-4 and ADAM33 gene polymorphisms with asthma in an Indian population.
Article in Lung, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Interleukin 4 gene polymorphism (-589C/T) and the risk of asthma: a meta-analysis and met-regression based on 55 studies.BMC immunology · 2020Pooled it
- Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Association between promoter polymorphisms of interleukin-4 gene and allergic rhinitis risk: a meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Pooled it
- Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Association betweenDiagnostics (Basel, Switzerland) · 2023Article
- Haplotype analysis ofThe Indian journal of medical research · 2019Article
- Article
- The recurrence risk of genetic complex diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- A preliminary study on the association of single nucleotide polymorphisms of interleukin 4 (IL4), IL13, IL4 receptor alpha (IL4Rα) & Toll-like receptor 4 (TLR4) genes with asthma in Indian adults.The Indian journal of medical research · 2015Article
- Genetic basis of asthma.The Indian journal of medical research · 2015Review
- Exploration of the Genetic Epidemiology of Asthma: A Review, with a Focus on Prevalence in Children and Adolescents in the Caribbean.The West Indian medical journal · 2014Article
- Association of a disintegrin and metalloprotease 33 gene polymorphisms with asthma.Molecular and clinical oncology · 2014Article
- Association of ADAM33 gene polymorphisms with allergic asthma.Iranian journal of basic medical sciences · 2014Article
- Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.PloS one · 2014Article
- Unravelling the role of ADAM 33 in asthma.The Indian journal of medical research · 2013Article
- Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.Journal of genetics · 2011Article
- An understanding of the genetic basis of asthma.The Indian journal of medical research · 2011Review
- Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma.Allergy & rhinology (Providence, R.I.) · 2011Article
- A disintegrin and metalloprotease 33 polymorphism association with COPD in long-term tobacco smokers of the ethnic Kashmiri population of India.Lung India : official organ of Indian Chest SocietyArticle
- T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study.Annals of Saudi medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are more than 100 candidate genes of asthma located on 23 human chromosomes. Interleukin-4 (IL-4), located on chromosome 5q31, and ADAM33, located on chromosome 20p13, and some single nucleotide polymorphisms (SNPs) of these genes have been shown to be associated with asthma and its manifestations in different populations. The most prominent SNPs of IL-4 and ADAM33 are 589C>T and 400A>G, respectively. There are also controversial reports on the association of these SNPs with asthma. In the present study, we analyzed these two SNPs in 100 patients with asthma and 50 controls through PCR amplification and restriction digestion to evaluate association of these two SNPs with asthma. The nonsignificant differences were observed for the IL-4 promoter polymorphism C589T and the ADAM33 T1 polymorphism between asthmatic patients and controls (P = 0.638 and 0.943, respectively). Our data revealed that there is no association of these SNPs with asthma indicating that other SNPs of these genes or other genes might be involved in the manifestation of asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.