ArticleAnnals of dermatology2009
A global gene expression analysis of the peripheral blood mononuclear cells reveals the gene expression signature in psoriasis.
Article in Annals of dermatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by Fas ligand via cDNA microarray analysis.Experimental and therapeutic medicine · 2021Article
- Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis.Cell death & disease · 2021Article
- Review-Current Concepts in Inflammatory Skin Diseases Evolved by Transcriptome Analysis: In-Depth Analysis of Atopic Dermatitis and Psoriasis.International journal of molecular sciences · 2020Review
- Prediction of crucial epigenetically‑associated, differentially expressed genes by integrated bioinformatics analysis and the identification of S100A9 as a novel biomarker in psoriasis.International journal of molecular medicine · 2020Article
- Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis.Biomedical reports · 2019Article
- Interleukin-7 and Immunosenescence.Journal of immunology research · 2017Review
- CD19+ B cell subsets in the peripheral blood and skin lesions of psoriasis patients and their correlations with disease severity.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- IL7R gene expression network associates with human healthy ageing.Immunity & ageing : I & A · 2015Article
- Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.BMC genomics · 2013Article
- Psoriasis vulgaris and familial cancer risk- a population-based study.Hereditary cancer in clinical practice · 2013Article
- A subset of methylated CpG sites differentiate psoriatic from normal skin.The Journal of investigative dermatology · 2012Article
- Evaluation of Tyrosine Kinase-2 (TYK2) signaling pathway gene expression and the presence of the single-nucleotide polymorphism rs12720356 in the peripheral blood of patients with severe psoriasis and loss of systemic treatment response.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPsoriasis is a chronic inflammatory skin disease that affects approximately 1~3% of the general population.
objectiveWe performed cDNA microarray analysis with using the dendrimer labelling method to investigate the gene expression profile in the peripheral blood mononuclear cells (PBMCs) of psoriatic patients.
methodsThe peripheral blood mononuclear cells of 5 patients with psoriasis and 8 control subjects were used in the gene expression analyses of psoriasis.
resultsWe identified 212 differentially expressed genes that showed at least a two-fold induction and/or reduction in psoriatic patients. Among those, 63 genes, including CD44, CD56 and IL7R, were induced, while 139 genes, including the sphingosine kinase 1 and p16-INK genes, were reduced in the psoriatic patients.
conclusionWe can speculate that these genes may have a role for the pathogenesis of psoriasis via their affecting different cellular functions. Our results suggest a possible mechanism by which activated immune cells migrate from the blood to the skin in psoriatic patients, and we provide novel putative targets for developing drugs to treat psoriasis.
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