ArticleObesity (Silver Spring, Md.)2011
Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus.
Article in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Effect of continuous positive airway pressure on ventricular remodeling of patients with combined diabetes mellitus and obstructive sleep apnea: a cross-sectional study and follow-on randomized clinical trial.International journal of cardiology · 2025Trial
- The interaction among OSA, CPAP, and medications in patients with comorbid OSA and cardiovascular/cerebrovascular disease: a randomized controlled trial.BMC pulmonary medicine · 2022 · on this mapTrial
- The Effect of Continuous Positive Airway Pressure on Vascular Function and Cardiac Structure in Diabetes and Sleep Apnea. A Randomized Controlled Trial.Annals of the American Thoracic Society · 2020Trial
- Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea.Internal medicine journal · 2013Trial
- Effect of CPAP treatment on endothelial function and plasma CRP levels in patients with sleep apnea.Medical science monitor : international medical journal of experimental and clinical research · 2012Trial
- Effects of obstructive sleep apnea on vascular structure and function in adults with obesity and type 2 diabetes: a comparative study.Cardiovascular endocrinology & metabolism · 2025Article
- Effects of high dietary carbohydrate intake in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Sleep Apnea, Obesity, and Diabetes - an Intertwined Trio.Current diabetes reports · 2023Review
- Sleep apnea, metabolic disease, and the cutting edge of therapy.Metabolism: clinical and experimental · 2018Review
- Retinal Vascular Morphological Changes in Patients with Extremely Severe Obstructive Sleep Apnea Syndrome.Chinese medical journal · 2017Article
- Association between obstructive sleep apnea severity and endothelial dysfunction in patients with type 2 diabetes.Cardiovascular diabetology · 2017Article
- Peripheral and Autonomic Neuropathy in South Asians and White Caucasians with Type 2 Diabetes Mellitus: Possible Explanations for Epidemiological Differences.Journal of diabetes research · 2017Article
- Obstructive Sleep Apnoea and Vascular Disease in Patients with Type 2 Diabetes.European endocrinology · 2015Review
- Obstructive sleep apnoea syndrome, endothelial function and markers of endothelialization. Changes after CPAP.PloS one · 2015Observational
- Adult obstructive sleep apnoea.Lancet (London, England) · 2014Review
- Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives.Pulmonary medicine · 2014Review
- Obstructive sleep apnea and endothelial progenitor cells.Patient preference and adherence · 2013Review
- Quintessential risk factors: their role in promoting cognitive dysfunction and Alzheimer's disease.Neurochemical research · 2012Review
- Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes.American journal of respiratory and critical care medicine · 2012Article
- Biomarkers of sleep apnea.Chest · 2012Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Despite the high prevalence of obstructive sleep apnea (OSA) in type 2 diabetes mellitus (DM), the attributable vascular risk from each condition is unknown. We hypothesize that OSA may have a similar effect on vascular function as type 2 diabetes does. Healthy normal-weight subjects, healthy obese subjects, subjects with type 2 diabetes, and obese subjects with OSA were enrolled. Vascular function was assessed with brachial artery ultrasound for flow-mediated dilatation (FMD) and in skin microcirculation by laser Doppler flowmetry. One hundred fifty-three subjects were studied: healthy normal-weight controls (NCs) (n = 14), healthy obese controls (OCs) (n = 33), subjects with DM (n = 68), and obese subjects with OSA (n = 38). The DM group did not undergo sleep study and thus may have had subclinical OSA. The OSA and type 2 diabetes groups had impaired FMD as compared to both the normal-weight and OC groups (5.8 ± 3.8%, 5.4 ± 1.6% vs. 9.1 ± 2.5%, 8.3 ± 5.1%, respectively, P < 0.001, post hoc Fischer test). When referenced to the NC group, a multiple linear regression model adjusting for covariates found that baseline brachial artery diameter (β = -3.75, P < 0.001), OSA (β = -2.45, P = 0.02) and type 2 diabetes status (β = -2.31, P = 0.02), negatively predicted % FMD. OSA status did not seem to affect nitroglycerin-induced vasodilation (endothelium-independent) of the brachial artery or vascular function in the skin microcirculation. OSA impairs endothelial function in the brachial artery to a similar degree as type 2 diabetes does. OSA, however, does not appear to affect brachial endothelium-independent vasodilation or skin microcirculatory function. Treatment of OSA in patients with concomitant type 2 diabetes, therefore, may be a potential therapeutic option to improve macro-, but not microvascular outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.