ArticleAmerican journal of nephrology2010
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.
Article in American journal of nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Apolipoprotein L1 High-Risk Genotypes are Associated With Lupus Nephritis Incidence.Kidney international reports · 2026Article
- Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene.Medicine · 2020Observational
- I too, am America: a review of research on systemic lupus erythematosus in African-Americans.Lupus science & medicine · 2016Review
- Gene-gene and gene-environment interactions in apolipoprotein L1 gene-associated nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2014Review
- End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- MYH9 and APOL1 gene polymorphisms and the risk of CKD in patients with lupus nephritis from an admixture population.PloS one · 2014Article
- APOL1 and nephropathy progression in populations of African ancestry.Seminars in nephrology · 2013Review
- Article
- European genetic ancestry is associated with a decreased risk of lupus nephritis.Arthritis and rheumatism · 2012Article
- The new era of APOL1-associated glomerulosclerosis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2012Article
- Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis.Genes and immunity · 2012Article
- Target organ damage in African American hypertension: role of APOL1.Current hypertension reports · 2012Review
- The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.Nature reviews. Nephrology · 2011Review
- Arrest of the true culprit and acquittal of the innocent? Genetic revelations charge APOL1 variants with kidney disease susceptibility.International urology and nephrology · 2010Review
- Admixture mapping of end stage kidney disease genetic susceptibility using estimated mutual information ancestry informative markers.BMC medical genomics · 2010Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundAfrican Americans (AA) disproportionately develop lupus nephritis (LN) relative to European Americans and familial clustering supports causative genes. Since MYH9 underlies approximately 40% of end-stage renal disease (ESRD) in AA, we tested for genetic association with LN.
methodsSeven MYH9 single nucleotide polymorphisms (SNPs) and the E1 risk haplotype were tested for association with LN in three cohorts of AA.
resultsA preliminary analysis revealed that the MYH9 E1 risk haplotype was associated with ESRD in 25 cases with presumed systemic lupus erythematosus (SLE)-associated ESRD, compared to 735 non-SLE controls (odds ratio 3.1; p = 0.010 recessive). Replication analyses were performed in 583 AA with SLE in the PROFILE cohort (318 with LN; 265 with SLE but without nephropathy) and 60 AA from the NIH (39 with LN; 21 with SLE but without nephropathy). Analysis of the NIH and larger PROFILE cohorts, as well as a combined analysis, did not support this association.
conclusionsThese results suggest that AA with ESRD and coincident SLE who were recruited from dialysis clinics more likely have kidney diseases in the MYH9-associated spectrum of focal segmental glomerulosclerosis. PROFILE and NIH participants, recruited from rheumatology practices, demonstrate that MYH9 does not contribute substantially to the development of LN in AA.
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