ReviewJournal of applied physiology (Bethesda, Md. : 1985)2010
Local thermal control of the human cutaneous circulation.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02549534 (Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer), which is not on this map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 306 citations in OpenAlex.
- Natural history of changes in knee skin temperature following total knee arthroplasty: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Behaviour change interventions for the management of Raynaud's phenomenon: a systematic literature review.BMJ open · 2018Pooled it
- Precooling methods and their effects on athletic performance : a systematic review and practical applications.Sports medicine (Auckland, N.Z.) · 2013Pooled it
- Time-dependent microvascular and analgesic responses to cold compression in healthy adults: identifying the optimal cooling duration for recovery.European journal of applied physiology · 2026Trial
- Medical mud-pack treatment with different temperatures in patients with knee osteoarthritis.International journal of biometeorology · 2025Trial
- Acute effects of hypouricemia on endothelium, oxidative stress, and arterial stiffness: A randomized, double-blind, crossover study.Physiological reports · 2021Trial
- Effects of acute dietary nitrate supplementation on cold-induced vasodilation in healthy males.European journal of applied physiology · 2021Trial
- Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.Journal of the American Heart Association · 2019Trial
- Cryotherapy-Induced Persistent Vasoconstriction After Cutaneous Cooling: Hysteresis Between Skin Temperature and Blood Perfusion.Journal of biomechanical engineering · 2016Trial
- Cold-induced vasoconstriction may persist long after cooling ends: an evaluation of multiple cryotherapy units.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Trial
- Effects of Repeated Contrast Therapy on Forearm Microcirculatory and Neuromechanical Recovery After Climbing-Specific Fatigue in Amateur Climbers: A Randomized Controlled Trial.Journal of clinical medicine · 2026Article
- Beyond the flush: rethinking reactions to ethanol-based disinfectants.Journal of anesthesia · 2026Article
- Local heating increases skin gas acetone content independent of systemic metabolism.Scientific reports · 2026Article
- Local heating induces an increase in the pulse wave velocity in peripheral vessels.Scientific reports · 2026Article
- Quantifying skin microvascular function responses to distinct forms of heat stress in humans using optical coherence tomography.Experimental physiology · 2026Article
- Early detection of microcirculatory changes using simultaneous heated and unheated transcutaneous blood gas monitoring: a proof-of-concept study in a porcine lipopolysaccharide model of systemic inflammation.Frontiers in medicine · 2026Article
- Adaptive restoration of T-cell motility by cold acclimation through metabolic and transcriptional remodeling.Frontiers in immunology · 2026Article
- Microvascular Reactivity to Cutaneous Local Heating in the Paretic and Non-Paretic Legs of Chronic Stroke Survivors-A Pilot Study.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Wavelet Components of Photoplethysmography During Reactive Hyperemia: Absolute vs. Relative Metrics.Biology · 2025Article
- Electrochemical skin conductance is associated with peripheral tissue hypoperfusion in septic patients.Intensive care medicine experimental · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The level of skin blood flow is subject to both reflex thermoregulatory control and influences from the direct effects of warming and cooling the skin. The effects of local changes in temperature are capable of maximally vasoconstricting or vasodilating the skin. They are brought about by a combination of mechanisms involving endothelial, adrenergic, and sensory systems. Local warming initiates a transient vasodilation through an axon reflex, succeeded by a plateau phase due largely to nitric oxide. Both phases are supported by sympathetic transmitters. The plateau phase is followed by the die-away phenomenon, a slow reversal of the vasodilation that is dependent on intact sympathetic vasoconstrictor nerves. The vasoconstriction with local skin cooling is brought about, in part, by a postsynaptic upregulation of α(2c)-adrenoceptors and, in part, by inhibition of the nitric oxide system at at least two points. There is also an early vasodilator response to local cooling, dependent on the rate of cooling. The mechanism for that transient vasodilation is not known, but it is inhibited by intact sympathetic vasoconstrictor nerve function and by intact sensory nerve function.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.