ArticleThe Journal of biological chemistry2010
Stat3 directly controls the expression of Tbx5, Nkx2.5, and GATA4 and is essential for cardiomyocyte differentiation of P19CL6 cells.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Pooled it
- Effects of taurine on skeletal muscle in senescence-accelerated mice and C2C12 myoblasts and myotubes.Amino acids · 2026Article
- Alternative methods for developmental toxicity testing: features, status and future directions.Journal of veterinary science · 2025Review
- Epigenetic Regulation of Mammalian Cardiomyocyte Development.Epigenomes · 2024Review
- Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases.Frontiers in cardiovascular medicine · 2023Review
- Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling.Molecular biology of the cell · 2022Article
- Astragaloside IV promotes pharmacological effect ofFrontiers in pharmacology · 2022Article
- MiR-301a promotes embryonic stem cell differentiation to cardiomyocytes.World journal of stem cells · 2019Article
- Effects of Cardiovascular Risk Factors on Cardiac STAT3.International journal of molecular sciences · 2018Review
- The march of pluripotent stem cells in cardiovascular regenerative medicine.Stem cell research & therapy · 2018Review
- Cardiac Stem Cells in the Postnatal Heart: Lessons from Development.Stem cells international · 2018Review
- Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia.Circulation research · 2017Article
- Small molecules for reprogramming and transdifferentiation.Cellular and molecular life sciences : CMLS · 2017Review
- Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy.PloS one · 2017Article
- Silencing of TBX20 gene expression in rat myocardial and human embryonic kidney cells leads to cell cycle arrest in G2 phase.Molecular medicine reports · 2016Article
- Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.PloS one · 2016Article
- MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome.Scientific reports · 2015Article
- Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.Journal of geriatric cardiology : JGC · 2015Article
- EGF is required for cardiac differentiation of P19CL6 cells through interaction with GATA-4 in a time- and dose-dependent manner.Cellular and molecular life sciences : CMLS · 2015Article
- Pathway reporter genes define molecular phenotypes of human cells.BMC genomics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor Stat3 (signal transducer and activator of transcription 3) mediates many physiological processes, including embryogenesis, stem cell self-renewal, and postnatal survival. In response to gp130 receptor activation, Stat3 becomes phosphorylated by the receptor-associated Janus kinase, forms dimers, and enters the nucleus where it binds to Stat3 target genes and regulates their expression. In this report, we demonstrate that Stat3 binds directly to the promoters and regulates the expression of three genes that are essential for cardiac differentiation: Tbx5, Nkx2.5, and GATA4. We further demonstrate that Tbx5, Nkx2.5, and GATA4 expression is dependent on Stat3 in response to ligand treatment and during ligand-independent differentiation of P19CL6 cells into cardiomyocytes. Finally, we show that Stat3 is necessary for the differentiation of P19CL6 cells into beating cardiomyocytes. All together, these results demonstrate that Stat3 is required for the differentiation of cardiomyocytes through direct transcriptional regulation of Tbx5, Nkx2.5, and GATA4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.