ReviewThe Journal of biological chemistry2010
Oxytetracycline biosynthesis.
Review in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 112 citations in OpenAlex.
- The Oxytetracycline ProducerInternational journal of molecular sciences · 2026Article
- Sustainable Biocatalytic Cascades: A Versatile Tool in the Synthesis of Natural Products With Therapeutic Potential.Chembiochem : a European journal of chemical biology · 2026Review
- AI-Assisted Isolation of Bioactive Dipyrimicins fromJournal of natural products · 2026Article
- Droplet based microfluidic and miniaturization at high-throughput level to screening heterologous secondary metabolites in microbes: A critical review.Biotechnology letters · 2025Review
- Development of a versatile chassis for the efficient production of diverse type II polyketides.Nature communications · 2025Article
- Novel endophytic actinomycetes species Streptomyces panacea of Panax sokpayensis produce antimicrobial compounds against multidrug resistant Staphylococcus aureus.Scientific reports · 2025Article
- AI-assisted isolation of bioactive Dipyrimicins frombioRxiv : the preprint server for biology · 2025Article
- Discovery of a novel methionine biosynthetic routeApplied and environmental microbiology · 2024Article
- Optimizing oxytetracycline removal from aqueous solutions using activated carbon from barley lignocellulosic wastes with isotherms and thermodynamic studies.Scientific reports · 2024Article
- Antioxidant and Pro-Oxidant Properties of Selected Clinically Applied Antibiotics: Therapeutic Insights.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Morphological-metabolic analysis in Streptomyces rimosus microparticle-enhanced cultivations (MPEC).Bioprocess and biosystems engineering · 2024Article
- Eradication of Klebsiella pneumoniae pulmonary infection by silver oxytetracycline nano-structure.AMB Express · 2024Article
- BacteSign: Building a Findable, Accessible, Interoperable, and Reusable (FAIR) Database for Universal Bacterial Identification.Biosensors · 2024Article
- Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer.Microbial cell factories · 2023Article
- Polyphosphate Ester-Type Transporters Improve Antimicrobial Properties of Oxytetracycline.Antibiotics (Basel, Switzerland) · 2023Article
- Integration of the Microbiome, Metabolome and Transcriptome RevealsAnimals : an open access journal from MDPI · 2023Article
- Investigation of diverse biosynthetic secondary metabolites gene clusters using genome mining of indigenousIranian journal of microbiology · 2022Article
- Unraveling the Nature of Antibiotics: Is It a Cure or a New Hurdle to the Patient Treatment?Cureus · 2022Review
- Great diversity of KSFEMS microbes · 2022Article
- Heterologous Expression, Purification, and Characterization of Type II Polyketide Synthase Acyl Carrier Proteins.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes. Genetic and biochemical studies have illuminated most of the steps involved in the biosynthesis of OTC, which is detailed here as a representative case study in type II polyketide biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.