ArticlePediatric diabetes2011
A comparison of the baseline metabolic profiles between Diabetes Prevention Trial-Type 1 and TrialNet Natural History Study participants.
Article in Pediatric diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2022Article
- HOMA2-B enhances assessment of type 1 diabetes risk among TrialNet Pathway to Prevention participants.Diabetologia · 2022Article
- Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.Diabetes care · 2020Article
- Observational
- Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests.Pediatric diabetes · 2018Article
- Dysglycemia and Index60 as Prediagnostic End Points for Type 1 Diabetes Prevention Trials.Diabetes care · 2017Article
- Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?Diabetes care · 2017Article
- Article
- OGTT and random plasma glucose in the prediction of type 1 diabetes and time to diagnosis.Diabetologia · 2015Article
- Use of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) for improving the accuracy of the risk classification of type 1 diabetes.Diabetes care · 2014Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
Abstract
objectiveWe assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive.
methodsDiabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet Natural History Study (TNNHS) participants were screened for biochemical autoantibodies. In both studies, those determined to be autoantibody positive underwent baseline oral glucose tolerance tests (OGTTs) in which glucose and C-peptide were measured.
resultsThe percentage of those with an OGTT in the diabetic range was higher among the DPT-1 participants (10.0% of 956 vs. 6.4% of 645, p < 0.01). In a logistic regression analysis with adjustments for age and gender, the difference persisted (p < 0.01). Among those in the non-diabetic range (n = 860 for DPT-1 and n = 604 for the TNNHS), glucose levels were similar at all time points, except for higher fasting glucose levels in the TNNHS participants (p < 0.001). There was a higher percentage of impaired fasting glucose (IFG) in the TNNHS participants (10.9 vs. 6.7%, p < 0.01); however, with adjustments for age and gender, there was no longer a significant difference. There was no significant difference in the percentages with impaired glucose tolerance. C-peptide levels were much lower in the DPT-1 cohort at all OGTT time points (p < 0.001 for all). DISCUSSION: Differing criteria for autoantibody screening can result in marked differences in the baseline metabolic profiles of prospective participants of T1D prevention trials.
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Registered trials
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