ArticleInternational reviews of immunology2010
Neonatal sepsis and neutrophil insufficiencies.
Article in International reviews of immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Quality assessment of clinical practice guidelines for neonatal sepsis using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument: A systematic review of neonatal guidelines.Frontiers in pediatrics · 2022Pooled it
- Influence of a combination of probiotics on bacterial infections in very low birthweight newborns.Wiener klinische Wochenschrift · 2015Trial
- Pentaglobin (immunoglobulin M-enriched immunoglobulin) as adjuvant therapy for premature and very low-birth-weight neonates with sepsis.Indian journal of pharmacologyTrial
- Circulating DNA and Neutrophil-Derived Biomarkers in Neonatal Sepsis.International journal of molecular sciences · 2026Observational
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- Depletion of Neonatal Neutrophilic Cells Worsens the Outcome of E. coli Sepsis in Newborn Mice.European journal of immunology · 2026Article
- Gallbladder ascariasis complicated by chronic eosinophilic cholecystitis in a one-year-old infant: A case report.International journal of surgery case reports · 2025Article
- Article
- Characteristics of Neonatal Sepsis and Predictive Values of Polyfunctional Assessment of Umbilical Cord Neutrophils Based on Single Cell Proteomic Secretion.Inflammation · 2025Article
- Article
- Shaping immunity: the influence of the maternal gut bacteria on fetal immune development.Seminars in immunopathology · 2025Review
- Neutropenia Associated With Furosemide Administration in a Preterm Infant.Case reports in pediatrics · 2025Article
- Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease.Nature reviews. Immunology · 2023Review
- Increased Expression of Anaphylatoxin C5a-Receptor-1 in Neutrophils and Natural Killer Cells of Preterm Infants.International journal of molecular sciences · 2023Article
- Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia.Neonatology · 2023Article
- Early-Onset Neonatal Sepsis in Turkey: A Single-Center 7-Year Experience in Etiology and Antibiotic Susceptibility.Children (Basel, Switzerland) · 2022Article
- Article
- The emerging role of neutrophil extracellular traps in fungal infection.Frontiers in cellular and infection microbiology · 2022Review
- The Neonatal Innate Immune Response to Sepsis: Checkpoint Proteins as Novel Mediators of This Response and as Possible Therapeutic/Diagnostic Levers.Frontiers in immunology · 2022Review
- Composition of early life leukocyte populations in preterm infants with and without late-onset sepsis.PloS one · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sepsis has continuously been a leading cause of neonatal morbidity and mortality despite current advances in chemotherapy and patient intensive care facilities. Neonates are at high risk for developing bacterial infections due to quantitative and qualitative insufficiencies of innate immunity, particularly granulocyte lineage development and response to infection. Although antibiotics remain the mainstay of treatment, adjuvant therapies enhancing immune function have shown promise in treating sepsis in neonates. This article reviews current strategies for the clinical management of neonatal sepsis and analyzes mechanisms underlying insufficiencies of neutrophil defense in neonates with emphasis on new directions for adjuvant therapy development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.