ArticleEthnicity & disease2010
Maternal factors and disparities associated with oral clefts.
Article in Ethnicity & disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal Cigarette Smoking and Cleft Lip and Palate: A Systematic Review and Meta-Analysis.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Pooled it
- Article
- Orofacial Cleft and Its Association with Consanguineous Marriage and Other Risk Factors: A Case-control Study from a Tertiary Care Hospital in Jammu Province.International journal of clinical pediatric dentistry · 2024Article
- Orofacial Clefts and Maternal Risk Factors: A Population-Based Case-Control Study.Children (Basel, Switzerland) · 2024Article
- An intercontinental comparison of the influence of smoking on the occurrence of nonsyndromic cleft lip and palate: a meta-analysis and systematic review.Archives of craniofacial surgery · 2024Article
- Evaluation of facial pleasantness in patients with complete and unilateral cleft lip and palate rehabilitated and submitted to orofacial harmonization.Dental press journal of orthodontics · 2024Article
- Epidemiology of Nonsyndromic, Orofacial Clefts in Texas: Differences by Cleft Type and Presence of Additional Defects.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2023Article
- mEpigenetics · 2022Article
- Could maternal stress be a causal factor for nonsyndromic cleft lip and/or palate: A retrospective study.National journal of maxillofacial surgery · 2022Article
- Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997-2011.Occupational and environmental medicine · 2022Article
- Article
- The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries.Journal of global health · 2020Article
- OROFACIAL CLEFTS AND CARDIOVASCULAR RISK AND DISEASES: THE CAUSAL RELATIONSHIP AND ASSOCIATIONS.Annals of Ibadan postgraduate medicine · 2020Article
- Influence of Parental Exposure to Risk Factors in the Occurrence of Oral Clefts.Journal of dentistry (Shiraz, Iran) · 2020Article
- Proportion of Orofacial Clefts Attributable to Recognized Risk Factors.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2019Article
- Maternal exposures and risk of oral clefts in South Vietnam.Birth defects research · 2018Article
- Is there an association between maternal smoking and oral clefts?Evidence-based dentistry · 2018Article
- Nicotine Exposure During Pregnancy Results in Persistent Midline Epithelial Seam With Improper Palatal Fusion.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Parental cigarette smoking, transforming growth factor-alpha gene variant and the risk of orofacial cleft in Iranian infants.Iranian journal of basic medical sciences · 2016Article
- Risk factors involved in orofacial cleft predisposition - review.Open medicine (Warsaw, Poland) · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionThe epidemiology of oral clefts continually unfolds. Researchers have not reached consensus concerning the significance of maternal smoking, weight gain, diabetes, age, and education and the risk of oral clefts. The purpose of this study was to examine these factors associated with oral clefts in the US population.
methodsThe 2005 U.S. Natality Data File was utilized for this study. Bivariate analyses compared the characteristics of mothers of infants with and without oral clefts. Multivarlate analysis calculated adjusted odds ratios for various maternal characteristics overall and for each race/ethnic group.
resultsSignificant bivariate associations with oral clefts were found for maternal age, race/ethnicity, education, tobacco use, and pregnancy-associated hypertension. Multivariate models found maternal age (OR = 0.98), race/ethnicity (OR = 0.36) for non-Hispanic Blacks (OR = 0.79 for Hispanics), and tobacco use (OR = 1.66) significant after adjustment for covariates. Across all race/ethnic groups maternal age (OR = 0.98) and smoking (OR = 1.66) were significantly associated with increased risk for oral cleft (OC). Non-Hispanic Blacks and Hispanics were at lower risk for OC regardless of the presence or absence of pregnancy-associated hypertension.
conclusionsConsistent with previous studies, maternal smoking was found to be associated with an increased risk of oral clefts. This association was significant for non-Hispanic Whites but not for non-Hispanic Blacks and Hispanics. A small inverse association was observed between maternal age, pregnancy-associated hypertension and the risk of oral clefts. This study confirms relationships found in previous studies but cannot establish causality. Further investigations of the risk factors for oral clefts would benefit from the study of gene-environment interactions.
Indexed as
Identifiers
20521404PMC2994716What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.