ArticleMolecular imaging and biology2011
Evaluation of the temporal window for drug delivery following ultrasound-mediated membrane permeability enhancement.
Article in Molecular imaging and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Bioinspired FeDiscover nano · 2025Article
- Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review.Nanomaterials (Basel, Switzerland) · 2022Review
- Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment.Materials today. Bio · 2022Review
- A synergistic bactericidal effect of low-frequency and low-intensity ultrasound combined with levofloxacin-loaded PLGA nanoparticles on M. smegmatis in macrophages.Journal of nanobiotechnology · 2020Article
- In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer.International journal of nanomedicine · 2020Article
- In vitro potentiation of doxorubicin by unseeded controlled non-inertial ultrasound cavitation.Scientific reports · 2019Article
- Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy.Pharmaceutics · 2019Review
- Low-intensity ultrasound promotes the horizontal transfer of resistance genes mediated by plasmids in3 Biotech · 2018Article
- SPIO labeling of endothelial cells using ultrasound and targeted microbubbles at diagnostic pressures.PloS one · 2018Article
- Ultrasound Molecular Imaging and Drug Delivery.Molecular imaging and biology · 2017Review
- Synergistic efficacy of ultrasound, sonosensitizers and chemotherapy: a review.Therapeutic delivery · 2017Review
- Spatial and temporal profile of cisplatin delivery by ultrasound-assisted intravesical chemotherapy in a bladder cancer model.PloS one · 2017Article
- Focused ultrasound-mediated sonochemical internalization: an alternative to light-based therapies.Journal of biomedical optics · 2016Article
- In vitro methods to study bubble-cell interactions: Fundamentals and therapeutic applications.Biomicrofluidics · 2016Review
- Novel delivery approaches for cancer therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Sonoporation efficacy on SiHa cells in vitro at raised bath temperatures-experimental validation of a prototype sonoporation device.Journal of therapeutic ultrasound · 2015Article
- Nucleic acid delivery with microbubbles and ultrasound.Advanced drug delivery reviews · 2014Review
- Recent advances in molecular, multimodal and theranostic ultrasound imaging.Advanced drug delivery reviews · 2014Review
- Effect of ultrasound on the permeability of vascular wall to nano-emulsion droplets.Ultrasound in medicine & biology · 2013Article
- Quantitative evaluation of ultrasound-mediated cellular uptake of a fluorescent model drug.Molecular imaging and biology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeUltrasound-induced cavitation facilitates cellular uptake of drugs via increased membrane permeability. Here, the purpose was to evaluate the duration of enhanced membrane permeability following ultrasound treatment in cell culture. PROCEDURES: Optical chromophores with fluorescence intensity increasing 100-1,000-fold upon intercalation with nucleic acids served as smart agents for reporting cellular uptake. Opticell chambers with a monolayer of C6 cells were subjected to ultrasound in the presence of microbubbles followed by varying delays between 0 and 24 h before addition of Sytox Green optical contrast agent. Micro- and macroscopic fluorescence were used for qualitative and quantitative analysis.
resultsUp to 25% of viable cells showed uptake of contrast agent with a half time of 8 h, with cellular uptake persisting even at 24 h. Only cells exposed to ultrasound showed the effect.
conclusionThe temporal window of increased membrane permeability is much longer in these studies than previously suggested. This may have important repercussions for in vivo studies in which membrane permeability may be temporally separated from drug delivery.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.