ArticleCell stress & chaperones2010
Stress, genomes, and evolution.
Article in Cell stress & chaperones, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR.DNA repair · 2016Article
- Environmental stress induces trinucleotide repeat mutagenesis in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- The polymorphisms in the promoter of HSP90 gene and their association with heat tolerance of bay scallop.Cell stress & chaperones · 2015Article
- Identity and function of a large gene network underlying mutagenic repair of DNA breaks.Science (New York, N.Y.) · 2012Article
- Degeneracy allows for both apparent homogeneity and diversification in populations.Bio Systems · 2012Article
- Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble.Cell cycle (Georgetown, Tex.) · 2011Article
- Stress-induced modulators of repeat instability and genome evolution.Journal of molecular microbiology and biotechnology · 2011Review
- What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Journal of molecular microbiology and biotechnology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Evolutionary change, whether in populations of organisms or malignant tumor cells, is contingent on the availability of inherited variation for natural selection to act upon. It is becoming clear that the Hsp90 chaperone, which normally functions to buffer client proteins against the effects of genetic variation, plays a central role in this process. Severe environmental stress can overwhelm the chaperone's buffering capacity, causing previously cryptic genetic variation to be expressed. Recent studies now indicate that in addition to exposing existing variation, Hsp90 can induce novel epigenetic and genetic changes. We discuss key findings that suggest a rich set of pathways by which Hsp90 can mediate the influences of the environment on the genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.