ArticlePloS one2010
Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Methylation of tumour suppressor genes in benign and malignant salivary gland tumours: a systematic review and meta-analysis.Epigenetics · 2022Pooled it
- Associations of RASSF1A, RARβ, and CDH1 promoter hypermethylation with oral cancer risk: A PRISMA-compliant meta-analysis.Medicine · 2018Pooled it
- Epigenetic alterations in head and neck cancer: a brief update.Virchows Archiv : an international journal of pathology · 2026Review
- The Epigenesis of Salivary Glands Carcinoma: From Field Cancerization to Carcinogenesis.Cancers · 2023Review
- Salivary gland carcinoma: Prediction of cancer death risk based on apparent diffusion coefficient histogram profiles.PloS one · 2018Article
- Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening.International journal of oncology · 2016Article
- Genetic alterations in salivary gland cancers.Cancer · 2016Review
- Epigenetic screening of salivary gland mucoepidermoid carcinoma identifies hypomethylation of CLIC3 as a common alteration.Oral oncology · 2015Article
- Aquaporin-1 promoter hypermethylation is associated with improved prognosis in salivary gland adenoid cystic carcinoma.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2014Article
- Molecular biology of adenoid cystic carcinoma.Head & neck · 2012Review
- Salivary gland carcinomas.Oral and maxillofacial surgery · 2012Review
- CXCL12 G801A polymorphism is associated with an increased risk of benign salivary gland tumors in the Chinese population.Medical oncology (Northwood, London, England) · 2012Article
- Salivary gland cancers: biology and molecular targets for therapy.Current oncology reports · 2012Article
- CpG array analysis of histone H3 lysine 4 trimethylation by chromatin immunoprecipitation linked to microarrays analysis in peripheral blood mononuclear cells of IgA nephropathy patients.Yonsei medical journal · 2012Article
- Suprabasin is hypomethylated and associated with metastasis in salivary adenoid cystic carcinoma.PloS one · 2012Article
- Role of DNA methylation in head and neck cancer.Clinical epigenetics · 2011Article
- Article
- Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011Article
- Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma.Oral oncology · 2011Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMethylation profiling of tumor suppressor gene (TSGs) promoters is quickly becoming a powerful diagnostic tool for the early detection, prognosis, and even prediction of clinical response to treatment. Few studies address this in salivary gland tumors (SGTs); hence the promoter methylation profile of various TSGs was quantitatively assessed in primary SGT tissue to determine if tumor-specific alterations could be detected. METHODOLOGY: DNA isolated from 78 tumor and 17 normal parotid gland specimens was assayed for promoter methylation status of 19 TSGs by fluorescence-based, quantitative methylation-specific PCR (qMSP). The data were utilized in a binary fashion as well as quantitatively (using a methylation quotient) allowing for better profiling and interpretation of results. PRINCIPAL
findingsThe average number of methylation events across the studied genes was highest in salivary duct carcinoma (SDC), with a methylation value of 9.6, compared to the normal 4.5 (p<0.0003). There was a variable frequency and individual methylation quotient detected, depending on the TSG and the tumor type. When comparing normal, benign, and malignant SGTs, there was a statistically significant trend for increasing methylation in APC, Mint 1, PGP9.5, RAR-beta, and Timp3. CONCLUSIONS/SIGNIFICANCE: Screening promoter methylation profiles in SGTs showed considerable heterogeneity. The methylation status of certain markers was surprisingly high in even normal salivary tissue, confirming the need for such controls. Several TSGs were found to be associated with malignant SGTs, especially SDC. Further study is needed to evaluate the potential use of these associations in the detection, prognosis, and therapeutic outcome of these rare tumors.
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