ArticleThe Journal of investigative dermatology2010
The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
Article in The Journal of investigative dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats.Pharmaceutics · 2026Article
- Amyloid Precursor Protein Processing Links Female Urgency Urinary Incontinence with Alzheimer's Disease: Implications for Treatment.International journal of molecular sciences · 2026Article
- The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications.Journal of cell communication and signaling · 2026Review
- Mediator 1 ablation induces enamel-to-hair lineage conversion in mice through enhancer dynamics.Communications biology · 2023Article
- Role of vitamin D and calcium signaling in epidermal wound healing.Journal of endocrinological investigation · 2023Review
- Chromatin Reorganization during Myoblast Differentiation Involves the Caspase-Dependent Removal of SATB2.Cells · 2022Article
- Loss of Mediator complex subunit 13 (MED13) promotes resistance to alkylation through cyclin D1 upregulation.Nucleic acids research · 2021Article
- Deletion of Mediator 1 suppresses TGFβ signaling leading to changes in epidermal lineages and regeneration.PloS one · 2020Article
- The potential role of circRNA_004229 in hair/epidermal regulation after MED1 ablation in keratinocytes.RSC advances · 2019Article
- Mediator 1 contributes to enamel mineralization as a coactivator for Notch1 signaling and stimulates transcription of the alkaline phosphatase gene.The Journal of biological chemistry · 2017Article
- Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization.Endocrinology · 2017Article
- Extraskeletal actions of vitamin D.Annals of the New York Academy of Sciences · 2016Review
- Relationship between Structure and Conformational Change of the Vitamin D Receptor Ligand Binding Domain in 1α,25-Dihydroxyvitamin D3 Signaling.Molecules (Basel, Switzerland) · 2015Review
- Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS.The Journal of steroid biochemistry and molecular biology · 2015Review
- Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation.The Journal of steroid biochemistry and molecular biology · 2014Review
- ERK oscillation-dependent gene expression patterns and deregulation by stress response.Chemical research in toxicology · 2014Article
- Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo.International journal of oncology · 2014Article
- Ablation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair.PloS one · 2014Article
- Molecular link between vitamin D and cancer prevention.Nutrients · 2013Review
- Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function.Best practice & research. Clinical endocrinology & metabolism · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Mediator is a multisubunit coactivator complex that facilitates transcription of nuclear receptors. We investigated the role of the mediator complex as a coactivator for vitamin D receptor (VDR) in keratinocytes. Using VDR affinity beads, the vitamin D receptor interacting protein (DRIP)/mediator complex was purified from primary keratinocytes, and its subunit composition was determined by mass spectrometry. The complex included core subunits, such as DRIP205/MED1 (MED1), that directly binds to VDR. Additional subunits were identified that are components of the RNA polymerase II complex. The functions of different mediator components were investigated by silencing its subunits. The core subunit MED1 facilitates VDR activity and regulating keratinocyte proliferation and differentiation. A newly described subunit MED21 also has a role in promoting keratinocyte proliferation and differentiation, whereas MED10 has an inhibitory role. Blocking MED1/MED21 expression caused hyperproliferation of keratinocytes, accompanied by increases in mRNA expression of the cell cycle regulator cyclin D1 and/or glioma-associated oncogene homolog. Blocking MED1 or MED21 expression also resulted in defects in calcium-induced keratinocyte differentiation, as indicated by decreased expression of differentiation markers and decreased translocation of E-cadherin to the membrane. These results show that keratinocytes use the transcriptional coactivator mediator to regulate VDR functions and control keratinocyte proliferation and differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.