ArticlePediatric research2010
Development of a symptom score for clinical studies to identify children with a documented viral upper respiratory tract infection.
Article in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Diagnostic models predicting paediatric viral acute respiratory infections: a systematic review.BMJ open · 2023Pooled it
- Duration of symptoms of respiratory tract infections in children: systematic review.BMJ (Clinical research ed.) · 2013Pooled it
- Echinacea reduces antibiotic usage in children through respiratory tract infection prevention: a randomized, blinded, controlled clinical trial.European journal of medical research · 2021Trial
- Lessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold.BMC complementary and alternative medicine · 2012Trial
- Exploring behavioural factors affecting nutritional supplement use among children in Honduras.Public health nutrition · 2022Article
- Review
- Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19.Viruses · 2021Article
- Effect of upper respiratory infection on anaesthesia induced atelectasis in paediatric patients.Scientific reports · 2021Article
- Safety and Dose-Dependent Effects ofChildren (Basel, Switzerland) · 2020Article
- Utility of predictive tools for risk stratification of elderly individuals with all-cause acute respiratory infection.Infection · 2019Article
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The objective of this study was to develop a symptom scoring system for use in clinical studies that differentiates children with cold symptoms who have an identifiable viral etiology for their upper respiratory tract infection (URI) from those in whom no virus is detected. Nasal swabs for PCR testing for identification of respiratory viruses were obtained on children aged 2-11 y at baseline and when parents thought their child was developing a cold. Parental-recorded severity of specific symptoms in children with and without a documented viral URI were compared. Nasal swabs were obtained on 108 children whose parents reported their child was developing a cold. A viral etiology was identified in 62 of 108 (57.4%) samples. Symptom measures that best differentiated children with a viral etiology from those without were significant runny nose and significant cough on days 1-4 of the illness. A URI symptom score was developed based on these symptoms, with a sensitivity of 81.4%, specificity of 61.9%, and accuracy of 73.3%. Parental impression is only a moderately accurate predictor of viral URI in children. Our URI symptom score provided a more accurate method for identifying children with viral URIs for clinical studies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.