ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Cutting edge: FcR-like 5 on innate B cells is targeted by a poxvirus MHC class I-like immunoevasin.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Natural Immunomodulatory Agents as a Complementary Therapy for Poxviruses.Advances in experimental medicine and biology · 2024Review
- Human Monkeypox: A Comprehensive Overview of Epidemiology, Pathogenesis, Diagnosis, Treatment, and Prevention Strategies.Pathogens (Basel, Switzerland) · 2023Review
- Poxviruses and the immune system: Implications for monkeypox virus.International immunopharmacology · 2022Review
- Review
- The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- FCRL regulation in innate-like B cells.Annals of the New York Academy of Sciences · 2015Review
- Article
- Developing the IVIG biomimetic, hexa-Fc, for drug and vaccine applications.Scientific reports · 2015Article
- Emerging roles for the FCRL family members in lymphocyte biology and disease.Current topics in microbiology and immunology · 2014Review
- FCRL3 promotes TLR9-induced B-cell activation and suppresses plasma cell differentiation.European journal of immunology · 2013Article
- FCRL5 exerts binary and compartment-specific influence on innate-like B-cell receptor signaling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- NK cells and poxvirus infection.Frontiers in immunology · 2013Article
- Crystal structure of the cowpox virus-encoded NKG2D ligand OMCP.Journal of virology · 2013Article
- A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.Arthritis and rheumatism · 2012Article
- FcR-like 2 Inhibition of B cell receptor-mediated activation of B cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Modulation of the host immune response by cowpox virus.Microbes and infection · 2010Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Under selective pressure from host immunity, viruses have retained genes encoding immunoevasins, molecules interfering with host viral recognition and clearance. Due to their binding specificities, immunoevasins can be exploited as affinity labels to identify host-encoded molecules of previously unsuspected importance in defense against the relevant class of virus. We previously described an orthopoxvirus MHC class I-like protein (OMCP) that binds with high affinity to the activating receptor NKG2D on NK and T cell subsets, implicating NKG2D in antiorthopoxvirus immunity. In this study, we report that OMCP also binds in an NKG2D-independent manner to B cells and monocytes/macrophages. We identify murine FcR-like 5 (FCRL5), an orphan immunoregulatory protein highly expressed by innate B lymphocytes, as a specific receptor for OMCP. The three N-terminal Ig domains of FCRL5 are required for OMCP binding. The targeting of FCRL5 by an orthopoxvirus immunoevasin strongly implicates it in contributing to host defense against zoonotic orthopoxviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.