ArticleThe American journal of tropical medicine and hygiene2010
Antivenomic assessment of the immunological reactivity of EchiTAb-Plus-ICP, an antivenom for the treatment of snakebite envenoming in sub-Saharan Africa.
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- Diversity of Phospholipases AToxins · 2022Article
- Intrageneric cross-reactivity of monospecific rabbit antisera against venoms of the medically most important Bitis spp. and Echis spp. African snakes.PLoS neglected tropical diseases · 2022Article
- Virus-like particles displaying conserved toxin epitopes stimulate polyspecific, murine antibody responses capable of snake venom recognition.Scientific reports · 2022Article
- Immunorecognition and Neutralization ofToxins · 2022Article
- Landscape of research, production, and regulation in venoms and antivenoms: a bibliometric analysis.Revista panamericana de salud publica = Pan American journal of public health · 2021Article
- Preclinical validation of a repurposed metal chelator as an early-intervention therapeutic for hemotoxic snakebite.Science translational medicine · 2020Article
- Antibody Cross-Reactivity in Antivenom Research.Toxins · 2018Review
- Third Generation Antivenomics: Pushing the Limits of the In Vitro Preclinical Assessment of Antivenoms.Toxins · 2017Article
- Article
- A Simple and Novel Strategy for the Production of a Pan-specific Antiserum against Elapid Snakes of Asia.PLoS neglected tropical diseases · 2016Article
- African adders: partial characterization of snake venoms from three Bitis species of medical importance and their neutralization by experimental equine antivenoms.PLoS neglected tropical diseases · 2015Article
- Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.The American journal of tropical medicine and hygiene · 2014Article
- Snake Venom Cytotoxins, Phospholipase AJournal of clinical toxicology · 2014Article
- Comparison of phylogeny, venom composition and neutralization by antivenom in diverse species of bothrops complex.PLoS neglected tropical diseases · 2013Article
- New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India.The Indian journal of medical research · 2013Review
- Consequences of neglect: analysis of the sub-Saharan African snake antivenom market and the global context.PLoS neglected tropical diseases · 2012Article
- Clinical toxinology.Current infectious disease reports · 2011Article
- Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities.Journal of venom research · 2010Article
Corrections and comments
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Authors and funding
13 authors.
Funding
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Abstract
The immunoreactivity of EchiTAb-Plus-ICP, an antivenom developed for the treatment of snakebite envenoming in sub-Saharan Africa, to venoms of seven Echis and Bitis species, was assessed by "antivenomics." This proteomic approach is based on the ability of an antivenom to immunodeplete homologous or heterologous venom proteins. Our results show an extensive cross-reactivity of this antivenom against all Echis and Bitis venoms studied, as revealed by the complete immunodepletion of the majority of venom components, including metalloproteinases, serine proteinases, C-type lectin-like proteins, some phospholipases A(2) and L-amino acid oxidase. However, some phospholipases A(2), disintegrins and proteinase inhibitors were immunodepleted to only a partial extent. These results support the hypothesis that immunizing horses with a mixture of the venoms of Echis ocellatus, Bitis arietans, and Naja nigricollis generates antibodies capable of recognizing the majority of components of medically-relevant homologous and heterologous viperid venoms of the genera Bitis and Echis from sub-Saharan Africa.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.