ArticleThe American journal of tropical medicine and hygiene2010
An insight into the sialotranscriptome of Simulium nigrimanum, a black fly associated with fogo selvagem in South America.
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Sialotranscriptome of Simulium pertinax and functional characterization of SpVaP: a novel recombinant simuliid-specific vasodilator.Molecular and cellular biochemistry · 2026Article
- A Global View of Pemphigus: Geographical Variations.Clinical reviews in allergy & immunology · 2024Review
- Risk of Attacks by Blackflies (Diptera: Simuliidae) and Occurrence of Severe Skin Symptoms in Bitten Patients along the Eastern Border of the European Union.International journal of environmental research and public health · 2022Article
- From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus.Frontiers in immunology · 2022Review
- Human immune response against salivary antigens of Simulium damnosum s.l.: A new epidemiological marker for exposure to blackfly bites in onchocerciasis endemic areas.PLoS neglected tropical diseases · 2021Article
- Implicating bites from a leishmaniasis sand fly vector in the loss of tolerance in pemphigus.JCI insight · 2020Article
- Characterization of IgE-binding proteins in the salivary glands of Simulium nigrogilvum (Diptera: Simuliidae).Parasitology research · 2019Article
- Chromosomal Translocations in Black Flies (Diptera: Simuliidae)-Facilitators of Adaptive Radiation?PloS one · 2016Article
- A cecropin-like antimicrobial peptide with anti-inflammatory activity from the black fly salivary glands.Parasites & vectors · 2015Article
- Purification and characterization of a novel defensin from the salivary glands of the black fly, Simulium bannaense.Parasites & vectors · 2015Article
- Update on fogo selvagem, an endemic form of pemphigus foliaceus.The Journal of dermatology · 2015Review
- Simplagrin, a platelet aggregation inhibitor from Simulium nigrimanum salivary glands specifically binds to the Von Willebrand factor receptor in collagen and inhibits carotid thrombus formation in vivo.PLoS neglected tropical diseases · 2014Article
- Profile of Trypanosoma cruzi reactivity in a population at high risk for endemic pemphigus foliaceus (Fogo selvagem).The American journal of tropical medicine and hygiene · 2012Article
- An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America.The American journal of tropical medicine and hygiene · 2012Article
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- An insight into the sialome of Simulium guianense (DIPTERA:SIMulIIDAE), the main vector of River Blindness Disease in Brazil.BMC genomics · 2011Article
- Sequence analysis of lysozyme C from the scorpion mesobuthus eupeus venom glands using semi-nested rt-PCR.Iranian Red Crescent medical journal · 2011Article
- Pathogenesis of endemic pemphigus foliaceus.Dermatologic clinics · 2011Review
- Diagnosis and clinical features of pemphigus foliaceus.Dermatologic clinics · 2011Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
Pemphigus foliaceus is a life threatening skin disease that is associated with autoimmunity to desmoglein, a skin protein involved in the adhesion of keratinocytes. This disease is endemic in certain areas of South America, suggesting the mediation of environmental factors triggering autoimmunity. Among the possible environmental factors, exposure to bites of black flies, in particular Simulium nigrimanum has been suggested. In this work, we describe the sialotranscriptome of adult female S. nigrimanum flies. It reveals the complexity of the salivary potion of this insect, comprised by over 70 distinct genes within over 30 protein families, including several novel families, even when compared with the previously described sialotranscriptome of the autogenous black fly, S. vittatum. The uncovering of this sialotranscriptome provides a platform for testing pemphigus patient sera against recombinant salivary proteins from S. nigrimanum and for the discovery of novel pharmacologically active compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.