ArticleThe American journal of clinical nutrition2010
Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 5 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 5 syntheses or guidelines pooled it, 218 citations in OpenAlex.
- Effect of dietary diversity on depression and depressive symptoms: a systematic review and meta-analysis of cross-sectional studies.BMC public health · 2025Pooled it
- The role of selenium in depression: a systematic review and meta-analysis of human observational and interventional studies.Scientific reports · 2022Pooled it
- Evidence of the Importance of Dietary Habits Regarding Depressive Symptoms and Depression.International journal of environmental research and public health · 2020Pooled it
- The risk factors for depression in cancer patients undergoing chemotherapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Pooled it
- Serum 25-hydroxyvitamin D levels and the risk of depression: a systematic review and meta-analysis.The journal of nutrition, health & aging · 2013Pooled it
- High Dose Vitamin B6 Reduces Depression Symptoms.Depression and anxiety · 2026Trial
- Evaluation of Nutritional Status of Patients with Depression.BioMed research international · 2015Trial
- A multi-nutrient supplement reduced markers of inflammation and improved physical performance in active individuals of middle to older age: a randomized, double-blind, placebo-controlled study.Nutrition journal · 2011Trial
- Association between serum vitamin BThe British journal of nutrition · 2026Article
- Metabolic syndrome is independently associated with 1-year readmission in patients with alcohol-associated cirrhosis.Frontiers in medicine · 2026Article
- Characterization of Gut Microbiome Composition in Depression and Completed Suicide.International journal of molecular sciences · 2025Article
- The association of vitamin deficiency with depression risk in late-life depression: a review.Frontiers in nutrition · 2025Review
- Religious Involvement, Vegetarian Diet, and Mental Well-Being Among Seventh-day Adventists in Peru.Journal of religion and health · 2024Article
- Fueling the Firefighter and Tactical Athlete with Creatine: A Narrative Review of a Key Nutrient for Public Safety.Nutrients · 2024Review
- Electrochemical sensing of vitamin BScientific reports · 2024Article
- The Role of Water-Soluble Vitamins and Vitamin D in Prevention and Treatment of Depression and Seasonal Affective Disorder in Adults.Nutrients · 2024Review
- Vitamin BCurrent psychiatry reports · 2024Review
- Association between Oral Health and Depressive Symptoms in Chinese Older Adults: The Mediating Role of Dietary Diversity.Nutrients · 2024Article
- Epigenetics, Nutrition, and the Brain: Improving Mental Health through Diet.International journal of molecular sciences · 2024Review
- The effect of Mediterranean diet instructions on depression, anxiety, stress, and anthropometric indices: A randomized, double-blind, controlled clinical trial.Preventive medicine reports · 2023Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundB-vitamin deficiencies have been associated with depression; however, there is very little prospective evidence from population-based studies of older adults.
objectiveWe examined whether dietary intakes of vitamins B-6, folate, or vitamin B-12 were predictive of depressive symptoms over an average of 7.2 y in a community-based population of older adults.
designThe study sample consisted of 3503 adults from the Chicago Health and Aging project, an ongoing, population-based, biracial (59% African American) study in adults aged > or =65 y. Dietary assessment was made by food-frequency questionnaire. Incident depression was measured by the presence of > or =4 depressive symptoms from the 10-item version of the Center for Epidemiologic Studies Depression scale.
resultsThe logistic regression models, which used generalized estimating equations, showed that higher total intakes, which included supplementation, of vitamins B-6 and B-12 were associated with a decreased likelihood of incident depression for up to 12 y of follow-up, after adjustment for age, sex, race, education, income, and antidepressant medication use. For example, each 10 additional milligrams of vitamin B-6 and 10 additional micrograms of vitamin B-12 were associated with 2% lower odds of depressive symptoms per year. There was no association between depressive symptoms and food intakes of these vitamins or folate. These associations remained after adjustment for smoking, alcohol use, widowhood, caregiving status, cognitive function, physical disability, and medical conditions.
conclusionOur results support the hypotheses that high total intakes of vitamins B-6 and B-12 are protective of depressive symptoms over time in community-residing older adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.